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Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy

2023-09-13 Medical
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Release : 2023-09-13
Genre : Medical
Kind : eBook
Book Rating : 929/5 ( reviews)

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Book Synopsis Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy by : Noha Mousaad Elemam

Download or read book Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy written by Noha Mousaad Elemam. This book was released on 2023-09-13. Available in PDF, EPUB and Kindle. Book excerpt: One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.

Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy

2023-08-31 Science
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Release : 2023-08-31
Genre : Science
Kind : eBook
Book Rating : 705/5 ( reviews)

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Book Synopsis Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy by : Bo Kong

Download or read book Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy written by Bo Kong. This book was released on 2023-08-31. Available in PDF, EPUB and Kindle. Book excerpt:

Immuno-Oncology Crosstalk and Metabolism

2022-05-16 Medical
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Release : 2022-05-16
Genre : Medical
Kind : eBook
Book Rating : 266/5 ( reviews)

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Book Synopsis Immuno-Oncology Crosstalk and Metabolism by : Muzafar Ahmad Macha

Download or read book Immuno-Oncology Crosstalk and Metabolism written by Muzafar Ahmad Macha. This book was released on 2022-05-16. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.

Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment

2019-03-20
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Release : 2019-03-20
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Book Rating : 850/5 ( reviews)

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Book Synopsis Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment by : Yongsheng Li

Download or read book Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment written by Yongsheng Li. This book was released on 2019-03-20. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.

Tumor Microenvironment

2020-03-25 Medical
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Release : 2020-03-25
Genre : Medical
Kind : eBook
Book Rating : 62X/5 ( reviews)

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Book Synopsis Tumor Microenvironment by : Peter P. Lee

Download or read book Tumor Microenvironment written by Peter P. Lee. This book was released on 2020-03-25. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

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