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Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment

2019-03-20
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Release : 2019-03-20
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Kind : eBook
Book Rating : 850/5 ( reviews)

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Book Synopsis Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment by : Yongsheng Li

Download or read book Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment written by Yongsheng Li. This book was released on 2019-03-20. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.

The Heterogeneity of Cancer Metabolism

2018-06-26 Medical
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Release : 2018-06-26
Genre : Medical
Kind : eBook
Book Rating : 36X/5 ( reviews)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le. This book was released on 2018-06-26. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Immuno-Oncology Crosstalk and Metabolism

2022-05-16 Medical
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Release : 2022-05-16
Genre : Medical
Kind : eBook
Book Rating : 266/5 ( reviews)

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Book Synopsis Immuno-Oncology Crosstalk and Metabolism by : Muzafar Ahmad Macha

Download or read book Immuno-Oncology Crosstalk and Metabolism written by Muzafar Ahmad Macha. This book was released on 2022-05-16. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.

Immune Metabolism in Health and Tumor

2017-09-05 Medical
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Release : 2017-09-05
Genre : Medical
Kind : eBook
Book Rating : 704/5 ( reviews)

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Book Synopsis Immune Metabolism in Health and Tumor by : Bin Li

Download or read book Immune Metabolism in Health and Tumor written by Bin Li. This book was released on 2017-09-05. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a broad overview of the concepts and research findings in immunometabolism. The immune system is made up of numerous different cell types, pathways, and components that must be able to respond rapidly to a pathogen or cancer, but must also remain quiescent in the absence of challenges. Immune cells rely on metabolic pathways to adapt to changing environments and stimuli. Additionally, these cells can be modified in function or fate by fluctuations in available nutrients. The chapters in this book describe ways in which immune cells utilize and are regulated by metabolic pathways. Topics include how immune-cell metabolism shapes immune homeostasis, and how dysregulation of these pathways can lead to immune disorders. In different contexts, such as a tumor microenvironment, immune-cell function and identity may be modified not only by cytokines and checkpoint molecules, but also by nutrient availability and other metabolic stimuli. Transcriptional reprogramming confers many of the changes in immune cell metabolism that are seen when a T-cell, for example, undergoes activation or functional adaptation to different environments. Lastly, immune cells can destructively or protectively participate in human metabolic homeostasis or disorders. This book summarizes immune-metabolism from a variety of different perspectives, including the ways in which metabolic cues, pathways, and requirements of immune cells change in conditions of homeostasis and activation. The exploration of the significance of metabolic checkpoints and other cues, particularly in the context of cancer and immune disorders, may form the foundation for the development of therapeutics.

Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions

2021-12-09 Medical
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Release : 2021-12-09
Genre : Medical
Kind : eBook
Book Rating : 821/5 ( reviews)

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Book Synopsis Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions by : Debabrata Banerjee

Download or read book Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions written by Debabrata Banerjee. This book was released on 2021-12-09. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.

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