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Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy

2023-08-31 Science
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Release : 2023-08-31
Genre : Science
Kind : eBook
Book Rating : 705/5 ( reviews)

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Book Synopsis Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy by : Bo Kong

Download or read book Crosstalk between cancer-associated fibroblasts and tumor cells in the tumor microenvironment: An emerging target of anti-cancer immunotherapy written by Bo Kong. This book was released on 2023-08-31. Available in PDF, EPUB and Kindle. Book excerpt:

The Heterogeneity of Cancer Metabolism

2018-06-26 Medical
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Release : 2018-06-26
Genre : Medical
Kind : eBook
Book Rating : 36X/5 ( reviews)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le. This book was released on 2018-06-26. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy

2023-09-13 Medical
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Release : 2023-09-13
Genre : Medical
Kind : eBook
Book Rating : 929/5 ( reviews)

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Book Synopsis Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy by : Noha Mousaad Elemam

Download or read book Understanding the Crosstalk Between Immune Cells and the Tumor Microenvironment in Cancer and Its Implications for Immunotherapy written by Noha Mousaad Elemam. This book was released on 2023-09-13. Available in PDF, EPUB and Kindle. Book excerpt: One of the current challenges and failures of immunotherapy is in part due to the complex tumor microenvironment (TME) that provides a formidable barrier to immune infiltration and function. The TME consists of various cell types (tumor cells, fibroblasts, endothelial cells, and immune cells), soluble signaling molecules (cytokines, growth factors, and chemokines), and extracellular matrix. On another note, metabolic disturbances in various TME components, such as hypoxia, acidosis, lactate accumulation, and nutrient deprivation, can play a critical role in the tumor progression. Furthermore, genetic and epigenetic dysfunctions are known to be part of the characteristics of cancer development. The immune cells could have a pro- or anti-tumor role in the TME, and their activity might vary in the context of different cancers. Both innate and adaptive immune cells interact with tumor cells through direct contact or through chemokines and cytokines signaling, shaping the tumor's activity and response to therapy.

Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

2017-12-22 Medical
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Release : 2017-12-22
Genre : Medical
Kind : eBook
Book Rating : 77X/5 ( reviews)

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Book Synopsis Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy by : Pawel Kalinski

Download or read book Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy written by Pawel Kalinski. This book was released on 2017-12-22. Available in PDF, EPUB and Kindle. Book excerpt: The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume. The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Tumor-Associated Fibroblasts and their Matrix

2011-07-28 Medical
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Release : 2011-07-28
Genre : Medical
Kind : eBook
Book Rating : 596/5 ( reviews)

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Book Synopsis Tumor-Associated Fibroblasts and their Matrix by : Margareta M. Mueller

Download or read book Tumor-Associated Fibroblasts and their Matrix written by Margareta M. Mueller. This book was released on 2011-07-28. Available in PDF, EPUB and Kindle. Book excerpt: During the last 20 years it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on “Tumor-associated fibroblasts and their matrix” as part of the series on “Tumor-Microenvironment” is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor development and progression. They discuss their interaction with other players such as blood vessels and immune cells, and show novel perspectives for tumor therapy. This compilation of excellent contributions of the best known experts in this important field in cancer research and therapy is a must for all scientists engaged in basic and clinical research. Increasing evidence of successful targeting of both cellular and matrix components in tumor therapy renders this book of particular interest for scientists engaged in pharmaceutical industry searching for new components for cancer therapy.

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