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Tumor Cell Metabolism

2015-01-19 Medical
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Release : 2015-01-19
Genre : Medical
Kind : eBook
Book Rating : 247/5 ( reviews)

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Book Synopsis Tumor Cell Metabolism by : Sybille Mazurek

Download or read book Tumor Cell Metabolism written by Sybille Mazurek. This book was released on 2015-01-19. Available in PDF, EPUB and Kindle. Book excerpt: The four sections of this book cover cell and molecular biology of tumor metabolism, metabolites, tumor microenvironment, diagnostics and epigenetics. Written by international experts, it provides a thorough insight into and understanding of tumor cell metabolism and its role in tumor biology. The book is intended for scientists in cancer cell and molecular biology, scientists in drug and diagnostic development, as well as for clinicians and oncologists.

The Heterogeneity of Cancer Metabolism

2018-06-26 Medical
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Release : 2018-06-26
Genre : Medical
Kind : eBook
Book Rating : 36X/5 ( reviews)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le. This book was released on 2018-06-26. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Tumor Cell Metabolism and Autophagy as Therapeutic Targets

2021-02-24 Medical
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Release : 2021-02-24
Genre : Medical
Kind : eBook
Book Rating : 003/5 ( reviews)

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Book Synopsis Tumor Cell Metabolism and Autophagy as Therapeutic Targets by : Carlos Pérez-Plasencia

Download or read book Tumor Cell Metabolism and Autophagy as Therapeutic Targets written by Carlos Pérez-Plasencia. This book was released on 2021-02-24. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer as a Metabolic Disease

2012-05-18 Science
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Release : 2012-05-18
Genre : Science
Kind : eBook
Book Rating : 306/5 ( reviews)

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Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried. This book was released on 2012-05-18. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment

2019-03-20
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Release : 2019-03-20
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Kind : eBook
Book Rating : 850/5 ( reviews)

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Book Synopsis Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment by : Yongsheng Li

Download or read book Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment written by Yongsheng Li. This book was released on 2019-03-20. Available in PDF, EPUB and Kindle. Book excerpt: Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.

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