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Extrasynaptic GABAA Receptors

2014-09-22 Medical
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Release : 2014-09-22
Genre : Medical
Kind : eBook
Book Rating : 26X/5 ( reviews)

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Book Synopsis Extrasynaptic GABAA Receptors by : Adam C. Errington

Download or read book Extrasynaptic GABAA Receptors written by Adam C. Errington. This book was released on 2014-09-22. Available in PDF, EPUB and Kindle. Book excerpt: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

The GABA Receptors

2007-07-19 Medical
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Release : 2007-07-19
Genre : Medical
Kind : eBook
Book Rating : 133/5 ( reviews)

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Book Synopsis The GABA Receptors by : Salvatore J. Enna

Download or read book The GABA Receptors written by Salvatore J. Enna. This book was released on 2007-07-19. Available in PDF, EPUB and Kindle. Book excerpt: The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

The GABA Receptors

2007-11-17 Medical
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Release : 2007-11-17
Genre : Medical
Kind : eBook
Book Rating : 656/5 ( reviews)

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Book Synopsis The GABA Receptors by : Salvatore J. Enna

Download or read book The GABA Receptors written by Salvatore J. Enna. This book was released on 2007-11-17. Available in PDF, EPUB and Kindle. Book excerpt: The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

Jasper's Basic Mechanisms of the Epilepsies

2012-06-29 Medical
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Release : 2012-06-29
Genre : Medical
Kind : eBook
Book Rating : 540/5 ( reviews)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels. This book was released on 2012-06-29. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Glutamate and GABA Receptors and Transporters

2001-10-04 Science
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Release : 2001-10-04
Genre : Science
Kind : eBook
Book Rating : 818/5 ( reviews)

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Book Synopsis Glutamate and GABA Receptors and Transporters by : Jan Egebjerg

Download or read book Glutamate and GABA Receptors and Transporters written by Jan Egebjerg. This book was released on 2001-10-04. Available in PDF, EPUB and Kindle. Book excerpt: The ubiquitous presence of glutamate and GABA receptors in the nervous system makes these receptor systems pivotal to our understanding of neurotransmission. Cloning of the molecular components of these receptor systems has provided insights to the selectivity of many drugs and detailed characterisation at the molecular level is emerging. Moreover, continuous development of novel and selective drugs has revealed detailed information on the mechanism of receptor activation and regulation. However, the rapid development of different aspects of glutamate and GABA receptor research makes it increasingly difficult to establish a general view of the field. Studies of the receptors are a multi-disciplinary task employing many specialised techniques. This book conveys recent discoveries in a framework of the basic concepts in the field of glutamate and GABA receptor research. Glutamate and GABA Receptors and Transporters: Structure, Function and Pharmacology is suitable for postgraduate students studying ligand gated channels but also beneficial for industrial and academic research scientists in both the glutamate and GABA field. Universities offering programs in neuroscience, molecular pharmacology or medicinal chemistry will find this a valuable reference.

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