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Extrasynaptic GABAA Receptors

2014-09-22 Medical
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Release : 2014-09-22
Genre : Medical
Kind : eBook
Book Rating : 26X/5 ( reviews)

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Book Synopsis Extrasynaptic GABAA Receptors by : Adam C. Errington

Download or read book Extrasynaptic GABAA Receptors written by Adam C. Errington. This book was released on 2014-09-22. Available in PDF, EPUB and Kindle. Book excerpt: GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed “tonic” inhibition, has been described. Whereas synaptic GABAA receptors underlie classical “phasic” GABAA receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABAA receptor-mediated inhibition results from the activation of extrasynaptic receptors by low concentrations of ambient GABA. Extrasynaptic GABAA receptors are composed of receptor subunits that convey biophysical properties ideally suited to the generation of persistent inhibition and are pharmacologically and functionally distinct from their synaptic counterparts. This book highlights ongoing work examining the properties of recombinant and native extrasynaptic GABAA receptors and their preferential targeting by endogenous and clinically relevant agents. In addition, it emphasizes the important role of extrasynaptic GABAA receptors in GABAergic inhibition throughout the CNS and identifies them as a major player in both physiological and pathophysiological processes.

Jasper's Basic Mechanisms of the Epilepsies

2012-06-29 Medical
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Release : 2012-06-29
Genre : Medical
Kind : eBook
Book Rating : 540/5 ( reviews)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels. This book was released on 2012-06-29. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

The Role of Extrasynaptic GABAA Receptors in Regulation of Inhibitory Synapses

2012
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Release : 2012
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis The Role of Extrasynaptic GABAA Receptors in Regulation of Inhibitory Synapses by : Ce Zhang

Download or read book The Role of Extrasynaptic GABAA Receptors in Regulation of Inhibitory Synapses written by Ce Zhang. This book was released on 2012. Available in PDF, EPUB and Kindle. Book excerpt:

GABA And Glutamate

2018-03-21 Medical
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Release : 2018-03-21
Genre : Medical
Kind : eBook
Book Rating : 219/5 ( reviews)

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Book Synopsis GABA And Glutamate by : Janko Samardzic

Download or read book GABA And Glutamate written by Janko Samardzic. This book was released on 2018-03-21. Available in PDF, EPUB and Kindle. Book excerpt: This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.

The GABA Receptors

2007-07-19 Medical
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Release : 2007-07-19
Genre : Medical
Kind : eBook
Book Rating : 133/5 ( reviews)

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Book Synopsis The GABA Receptors by : Salvatore J. Enna

Download or read book The GABA Receptors written by Salvatore J. Enna. This book was released on 2007-07-19. Available in PDF, EPUB and Kindle. Book excerpt: The Gaba Receptors, Third Edition, presents a critical appraisal of our current understanding of the molecular, behavioral, biochemical, clinical, and pharmacological properties of GABA receptors. Emphasis is placed on exploring cutting-edge findings on the structureal properties of receptor sites, mechanisms of receptor expression, chemical agents that differentiate receptor subtypes, and phenotypes displayed by GABA receptor null mice. Chapters in this updated and expanded edition examine such topics as GABA receptor subypes, trafficking postsynaptic GABA receptors, GABA receptor mutations associated with idiopathic generalized epilepsies and febrile seizures, and GABA receptors as a potential therapeutic target.

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