Author : Richard I. Morimoto
Release : 2012-12-13
Genre : Medical
Kind : eBook
Book Rating : 287/5 ( reviews)
Book Synopsis Protein Quality Control in Neurodegenerative Diseases by : Richard I. Morimoto
Download or read book Protein Quality Control in Neurodegenerative Diseases written by Richard I. Morimoto. This book was released on 2012-12-13. Available in PDF, EPUB and Kindle. Book excerpt: The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.