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Quality Control of Cellular Protein in Neurodegenerative Disorders

2020-02-14 Medical
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Release : 2020-02-14
Genre : Medical
Kind : eBook
Book Rating : 185/5 ( reviews)

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Book Synopsis Quality Control of Cellular Protein in Neurodegenerative Disorders by : Uddin, Md. Sahab

Download or read book Quality Control of Cellular Protein in Neurodegenerative Disorders written by Uddin, Md. Sahab. This book was released on 2020-02-14. Available in PDF, EPUB and Kindle. Book excerpt: Protein misfolding and aggregation are hallmarks of several neurodegenerative proteinopathies. Though multiple factors like aging, oxidative stress, mitochondrial dysfunction, proteotoxic insults, genetic inconsistency, etc. are responsible for the dysfunction of the neuronal protein quality control system, targeting protein quality control has become an auspicious approach to halt the propagation of neurodegeneration. Quality Control of Cellular Protein in Neurodegenerative Disorders provides diverse aspects exploring the role of the protein quality control in neurodegenerative disorders and potential therapeutic strategies to combat the development and propagation of neurodegeneration. Featuring coverage on a broad range of topics such as molecular chaperones, protein misfolding, and stress signaling, this book is ideally designed for neurobiologists, neuropsychologists, neurophysiologists, medical professionals, neuropathologists, researchers, academicians, students, and practitioners engaged in studies of the protein quality control system in neuronal cells.

Protein Quality Control in Neurodegenerative Diseases

2012-12-13 Medical
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Release : 2012-12-13
Genre : Medical
Kind : eBook
Book Rating : 287/5 ( reviews)

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Book Synopsis Protein Quality Control in Neurodegenerative Diseases by : Richard I. Morimoto

Download or read book Protein Quality Control in Neurodegenerative Diseases written by Richard I. Morimoto. This book was released on 2012-12-13. Available in PDF, EPUB and Kindle. Book excerpt: The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

Protein Quality Control in Neurodegenerative Diseases

2012-12-12 Medical
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Release : 2012-12-12
Genre : Medical
Kind : eBook
Book Rating : 294/5 ( reviews)

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Book Synopsis Protein Quality Control in Neurodegenerative Diseases by : Richard I. Morimoto

Download or read book Protein Quality Control in Neurodegenerative Diseases written by Richard I. Morimoto. This book was released on 2012-12-12. Available in PDF, EPUB and Kindle. Book excerpt: The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

The Molecular and Cellular Basis of Neurodegenerative Diseases

2018-03-29 Medical
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Release : 2018-03-29
Genre : Medical
Kind : eBook
Book Rating : 057/5 ( reviews)

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Book Synopsis The Molecular and Cellular Basis of Neurodegenerative Diseases by : Michael S. Wolfe

Download or read book The Molecular and Cellular Basis of Neurodegenerative Diseases written by Michael S. Wolfe. This book was released on 2018-03-29. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, ALS, Huntington's, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. - Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features - Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration - Details features, advantages and limitations of animal models, as well as prospects for therapeutic development - Authored by internationally recognized leaders in the field - Includes illustrations that help clarify and consolidate complex concepts

Molecular Chaperones and Neurodegeneration

2017-12-06
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Release : 2017-12-06
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Kind : eBook
Book Rating : 421/5 ( reviews)

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Book Synopsis Molecular Chaperones and Neurodegeneration by : Cintia Roodveldt

Download or read book Molecular Chaperones and Neurodegeneration written by Cintia Roodveldt. This book was released on 2017-12-06. Available in PDF, EPUB and Kindle. Book excerpt: Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered and several molecular mechanisms have been elucidated for many chaperones, while the field is being continuously challenged by new open questions. Probably as a consequence of the increasing research on the molecular bases of neurodegenerative diseases, and the realisation that many such disorders are linked to protein misfolding processes, unleashing the roles and mechanisms of chaperones in the context of neurodegeneration has become a prime scientific goal. This e-book contains a diversity of reviews, perspective and original research articles highlighting the importance and potential of this emerging subject.

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