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Hypoxia in Cancer: Significance and Impact on Cancer Therapy

2023-04-13 Medical
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Release : 2023-04-13
Genre : Medical
Kind : eBook
Book Rating : 130/5 ( reviews)

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Book Synopsis Hypoxia in Cancer: Significance and Impact on Cancer Therapy by : Sukhes Mukherjee

Download or read book Hypoxia in Cancer: Significance and Impact on Cancer Therapy written by Sukhes Mukherjee. This book was released on 2023-04-13. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.

Tumor Oxygenation

1995 Medical
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Release : 1995
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Tumor Oxygenation by : Peter Vaupel

Download or read book Tumor Oxygenation written by Peter Vaupel. This book was released on 1995. Available in PDF, EPUB and Kindle. Book excerpt:

Hypoxia and Cancer

2013-11-09 Medical
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Release : 2013-11-09
Genre : Medical
Kind : eBook
Book Rating : 673/5 ( reviews)

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Book Synopsis Hypoxia and Cancer by : Giovanni Melillo

Download or read book Hypoxia and Cancer written by Giovanni Melillo. This book was released on 2013-11-09. Available in PDF, EPUB and Kindle. Book excerpt: ​​​The imbalance between rapidly proliferating tumor cells and inadequate and inefficient tumor vasculature leads to a decrease in oxygen levels (hypoxia and/or anoxia) in tumor tissues. Intra-tumor hypoxia profoundly affects the biological behavior of cancer cells, which become resistant to conventional therapies and acquire a more invasive and metastatic phenotype. Hypoxia is a hallmark of the malignant phenotype and a key feature of the tumor microenvironment. Hypoxia Inducible Factor 1 (HIF-1) is a master regulator of the transcriptional response to oxygen deprivation. HIF triggers the expression of genes whose products induce angiogenesis, decrease oxygen consumption, switch metabolism to glycolysis, maintain a stem cell phenotype and select for more invasive and metastatic cells. Therapeutic approaches targeting HIF, directly or downstream mediators of its transcriptional activity, are being developed. Intra-tumor hypoxia is a topic has been gaining scientific interest over the last few years for its wide involvement in many physiological and pathological processes. This volume will cover the latest research and translational aspects associated with intra-tumor hypoxia, along with opportunities for drug development offered by this unique feature of the tumor microenvironment. The ongoing efforts to translate our understanding of the biology underlying intra-tumor hypoxia in viable therapeutic options face many challenges, but this book will provide an opportunity for an in-depth analysis of the fundamental mechanisms implicated in the adaption to low oxygen levels and will scrutinize the potential for opportunities that are being pursued in both research and the drug development industry.

Hypoxia and Cancer Metastasis

2019-06-14 Medical
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Release : 2019-06-14
Genre : Medical
Kind : eBook
Book Rating : 346/5 ( reviews)

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Book Synopsis Hypoxia and Cancer Metastasis by : Daniele M. Gilkes

Download or read book Hypoxia and Cancer Metastasis written by Daniele M. Gilkes. This book was released on 2019-06-14. Available in PDF, EPUB and Kindle. Book excerpt: The present book is an attempt to provide a detailed review of studies that clarify our current understanding of the role of hypoxia in the progression of primary cancer to metastatic disease. It will enable researchers to discover the critical cellular changes that occur under hypoxic conditions and play a role in metastatic dissemination, from the activation of hypoxia-inducible factors, HIF-1 and HIF-2, to the transcriptional profile changes that occur in cancer cells and promote cancer cell survival under detrimental conditions. Readers will discover the methods and challenges involved in imaging and quantifying the degree of hypoxia in a primary tumor. We will provide an understanding of the hypoxia-induced phenotypes that influence heterogeneity, alter the secretome and tumor microenvironment, modify cellular metabolism, and promote immune suppression and resistance to chemotherapy. Finally, we will uncover the therapeutic strategies that are being devised to target the hypoxic microenvironment in the hopes of preventing metastasis and improving the efficacy of standard-of-care cancer treatments. This work is an up to date source of information on the challenges and complexity of the hypoxic tumor microenvironment. Basic and translational scientists, post-doctoral fellows, graduate students, and those interested in how tumors metastasize will find this book a reference that details how hypoxia influences metastatic disease.

Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics

2017-01-31
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Release : 2017-01-31
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Kind : eBook
Book Rating : 643/5 ( reviews)

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Book Synopsis Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics by : Christian R. Gomez

Download or read book Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics written by Christian R. Gomez. This book was released on 2017-01-31. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.

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