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Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics

2017-01-31
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Release : 2017-01-31
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Kind : eBook
Book Rating : 643/5 ( reviews)

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Book Synopsis Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics by : Christian R. Gomez

Download or read book Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics written by Christian R. Gomez. This book was released on 2017-01-31. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.

Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics

2017
Download Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics PDF Online Free

Author :
Release : 2017
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

GET EBOOK


Book Synopsis Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics by :

Download or read book Tumor Hypoxia: Impact in Tumorigenesis, Diagnosis, Prognosis and Therapeutics written by . This book was released on 2017. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.Hypoxic regions have been identified within tumors and its presence has been linked to malignant progression, metastasis, resistance to therapy, and poor clinical outcomes following treatment. Acute and chronic hypoxia are integral components of tumor microenvironment and conduce to metabolic adaptations of tumor cells leading to genetic instability, intratumor heterogeneity and malignant progression. On the success of our fight against cancer, the continued adaptability of tumors to their microenvironmental stresses, such as hypoxia, must be considered. Tumor cells are endowed with a very high plasticity and capacity to adapt. It is our challenge to find populations and conditions of the tumor microenvironment germane for target success. Interdisciplinary work will be the key for achievement of these goals. This e-book is a compendium of original reports and review articles contributed by world-class experts in the field of tumor hypoxia. This material will be useful to foster discussion and increase understanding of the involvement of hypoxia in tumorigenesis, biomarker development, and therapeutics.

Hypoxia in Cancer: Significance and Impact on Cancer Therapy

2023-04-13 Medical
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Release : 2023-04-13
Genre : Medical
Kind : eBook
Book Rating : 130/5 ( reviews)

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Book Synopsis Hypoxia in Cancer: Significance and Impact on Cancer Therapy by : Sukhes Mukherjee

Download or read book Hypoxia in Cancer: Significance and Impact on Cancer Therapy written by Sukhes Mukherjee. This book was released on 2023-04-13. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the central role of hypoxia in cancer initiation and progression. It discusses the mechanisms of hypoxia in chemoresistance, radioresistance, angiogenesis, vasculogenesis, metastasis, metabolic, and genomic instability. It also explores the potential of hypoxia in the diagnosis and treatment of cancer. The book provides an overview of hypoxia imaging, its biological relevance, and mechanism of action. It helps in understanding the molecular mechanisms of the regulation of senescence by hypoxia. It explores the contribution of hypoxia to immune resistance and immune suppression/tolerance and determines the hypoxia-responsive long non-coding RNAs in regulating hypoxic gene expression at chromatin, transcriptional, and post-transcriptional levels. Further, it presents the functional link between hypoxia and miRNA expressions and hypoxia-regulated miRNAs in cancer cell survival in a low oxygen environment. Lastly, it discusses the applications of tumor-on-a-chip technology for the understanding of hypoxia-tumor microenvironment. This book is a valuable source for oncologists and scientists working to understand the role of hypoxia in cancer and therapeutic approaches.

Diverse Effects of Hypoxia on Tumor Progression

2010-09-28 Medical
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Release : 2010-09-28
Genre : Medical
Kind : eBook
Book Rating : 290/5 ( reviews)

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Book Synopsis Diverse Effects of Hypoxia on Tumor Progression by : M. Celeste Simon

Download or read book Diverse Effects of Hypoxia on Tumor Progression written by M. Celeste Simon. This book was released on 2010-09-28. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxia, defined as reduced oxygen tension, is a common physiological phenomenon in both normal embryonic development and malignancy progression. Although severe hypoxia is generally toxic for both normal tissue and tumors, neoplastic cells gradually adapt to prolonged hypoxia though additional genetic and genomic changes with a net result that hypoxia promotes tumor progression and therapeutic resistance. Hypoxia promotes cancer progression by regulating various aspects of cancer biology, including radiotherapy resistance, metabolism, angiogenesis and invasion/migration

Cancer as a Metabolic Disease

2012-05-18 Science
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Release : 2012-05-18
Genre : Science
Kind : eBook
Book Rating : 306/5 ( reviews)

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Book Synopsis Cancer as a Metabolic Disease by : Thomas Seyfried

Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried. This book was released on 2012-05-18. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.

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