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Development of New Multicomponent Processes Based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications

2017
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Release : 2017
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Book Synopsis Development of New Multicomponent Processes Based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications by : Ouldouz Ghashghaei

Download or read book Development of New Multicomponent Processes Based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications written by Ouldouz Ghashghaei. This book was released on 2017. Available in PDF, EPUB and Kindle. Book excerpt:

Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid

2013
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Release : 2013
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Book Synopsis Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid by : Brett Adam Granger

Download or read book Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid written by Brett Adam Granger. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Several novel multicomponent assembly processes have been developed for the preparation of a diverse array of complex heterocyclic systems from relatively simple starting materials. These studies resulted in the discovery of a new quinazolone forming reaction, which was applied to the one-step synthesis of the quinazolinocarboline alkaloid rutaecarpine. Biological screening of these complex heterocycles culminated in the identification of a potent sigma-2 receptor ligand. A novel N-acyliminium ion mediated cascade reaction was employed for the concise synthesis of (±)-actinophyllic acid. The completion of the synthesis relied on the development of a reaction sequence that avoided a potentially detrimental fragmentation process. Furthermore, several anti-cancer compounds were identified through a diverted total synthesis approach.

Isocyanide-based Multicomponent Reactions

2020-02-20
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Release : 2020-02-20
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Book Rating : 841/5 ( reviews)

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Book Synopsis Isocyanide-based Multicomponent Reactions by : Jonathan G. Rudick

Download or read book Isocyanide-based Multicomponent Reactions written by Jonathan G. Rudick. This book was released on 2020-02-20. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Copper-Catalyzed Multi-Component Reactions

2011-01-20 Science
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Release : 2011-01-20
Genre : Science
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Book Rating : 735/5 ( reviews)

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Book Synopsis Copper-Catalyzed Multi-Component Reactions by : Yusuke Ohta

Download or read book Copper-Catalyzed Multi-Component Reactions written by Yusuke Ohta. This book was released on 2011-01-20. Available in PDF, EPUB and Kindle. Book excerpt: A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by catalytic domino reaction including multi-component coupling was developed, and is the first example of a three-component indole formation without producing salts as a byproduct. Based on this reaction, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was accomplished which represents an unprecedented isoquinoline synthesis through a four-component coupling reaction. Following these results, extensive application studies using one-pot palladium-, acid-, or base-promoted cyclization revealed that indole- or isoquinoline-fused polycyclic compounds can be readily synthesized through multi-component reactions. As the concept of Green Chemistry becomes ever more important, these findings may provide efficient and atom-economical approaches to the diversity-oriented synthesis of bioactive compounds containing a complex structure. This could lead to development of promising drug leads with structural complexity. The work of this thesis will go on to inspire the synthetic research of many readers.

Development of New Methods to Synthesize Heterocyclic Compounds

2021 Electronic dissertations
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Release : 2021
Genre : Electronic dissertations
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Book Synopsis Development of New Methods to Synthesize Heterocyclic Compounds by : Md Shafaat Al Mehedi

Download or read book Development of New Methods to Synthesize Heterocyclic Compounds written by Md Shafaat Al Mehedi. This book was released on 2021. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation is focused on the development of new methods to synthesize imidazoline scaffolds. The work discusses three new procedures developed in the Tepe lab to synthesize trans-oxazoline, trans-imidazoline, and 2,3-disubstituted quinoline scaffolds. In addition, a new guanidine base mediated diastereoselective aziridine synthesis is described in this work. These new synthetic methodologies provide access to compounds that were not easily accessible using previously described methods. Paths to oxazolines and imidazolines via modified Corey-Chaykovsky sulfur ylide chemistry are presented. Here, the sulfonium salts were treated with stable precursors of acyl imines and 1,3-diaza-1,3-butadiene intermediates, respectively, for the oxazoline and imidazoline syntheses. A modified Skraup-type reaction was employed to synthesize 2,3-disubstituted quinoline scaffolds where epoxides were treated with aromatic anilines under mild conditions in the presence of a Lewis acid.

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