Share

Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid

2013
Download Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid PDF Online Free

Author :
Release : 2013
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

GET EBOOK


Book Synopsis Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid by : Brett Adam Granger

Download or read book Development of Multicomponent Assembly Processes and Their Application to the Synthesis of Novel Heterocyclic Scaffolds and the Total Synthesis of Actinophyllic Acid written by Brett Adam Granger. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Several novel multicomponent assembly processes have been developed for the preparation of a diverse array of complex heterocyclic systems from relatively simple starting materials. These studies resulted in the discovery of a new quinazolone forming reaction, which was applied to the one-step synthesis of the quinazolinocarboline alkaloid rutaecarpine. Biological screening of these complex heterocycles culminated in the identification of a potent sigma-2 receptor ligand. A novel N-acyliminium ion mediated cascade reaction was employed for the concise synthesis of (±)-actinophyllic acid. The completion of the synthesis relied on the development of a reaction sequence that avoided a potentially detrimental fragmentation process. Furthermore, several anti-cancer compounds were identified through a diverted total synthesis approach.

Handbook of Science & Engineering of Green Corrosion Inhibitors

2021-11-19 Technology & Engineering
Download Handbook of Science & Engineering of Green Corrosion Inhibitors PDF Online Free

Author :
Release : 2021-11-19
Genre : Technology & Engineering
Kind : eBook
Book Rating : 13X/5 ( reviews)

GET EBOOK


Book Synopsis Handbook of Science & Engineering of Green Corrosion Inhibitors by : Chandrabhan Verma

Download or read book Handbook of Science & Engineering of Green Corrosion Inhibitors written by Chandrabhan Verma. This book was released on 2021-11-19. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Science and Engineering of Green Corrosion Inhibitors: Modern Theory, Fundamentals and Practical Applications presents developments in green corrosion inhibitors and current applications. The book provides an overview of green corrosion inhibitors such as plant extracts, chemical medicines, natural polymers, synthetic green compounds, carbohydrates, amino acids and oleochemicals that can cost-effectively minimize corrosive damage. The book handles several compounds used as anticorrosive materials for different metals and alloys in a versatile corrosive environment. Sections address the fundamental characteristics of green corrosion inhibition and deal with the economic impact of corrosion and forms of corrosion, while also assessing and classifying corrosion inhibitors. The book covers a broad range of applications in green corrosion inhibition and concludes with new emerging trends in corrosion protection such as high temperature corrosion and its protection and nanomaterials as corrosion inhibitors. - Provides an overview of environmentally sustainable (green) corrosion inhibitors utilized in modern industrial platforms - Evaluates corrosion inhibitors as prime options for sustainable and transformational opportunities - Serves as a valuable reference for scientists and engineers who are searching modern design for corrosion inhibitors - Covers both synthetic and natural environmentally-friendly corrosion inhibitors

The Development of a Four Component Reaction and Its Application to the Synthesis of Diverse Heterocyclic Scaffolds and the Total Synthesis of Alkaloid Natural Products

2009
Download The Development of a Four Component Reaction and Its Application to the Synthesis of Diverse Heterocyclic Scaffolds and the Total Synthesis of Alkaloid Natural Products PDF Online Free

Author :
Release : 2009
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

GET EBOOK


Book Synopsis The Development of a Four Component Reaction and Its Application to the Synthesis of Diverse Heterocyclic Scaffolds and the Total Synthesis of Alkaloid Natural Products by : James Dennis Sunderhaus

Download or read book The Development of a Four Component Reaction and Its Application to the Synthesis of Diverse Heterocyclic Scaffolds and the Total Synthesis of Alkaloid Natural Products written by James Dennis Sunderhaus. This book was released on 2009. Available in PDF, EPUB and Kindle. Book excerpt: A four component reaction involving the coupling of functionalized aldehydes, amines, acid chlorides, and [pi]- and organometallic nucleophiles has been developed to prepare multifunctional substrates that may be employed in subsequent ring-forming reactions to generate diverse arrays of functionalized heterocyclic scaffolds. Allyl metals, Grignard reagents, silyl ketene acetals, silyl enol ethers, and silyloxy furans have been utilized as the nucleophile in the four component reaction (4CR). The 4CR has been sequenced with intramolecular Heck reactions, Diels-Alder and (3+2) cycloadditions, ring closing metathesis (RCM), and Dieckmann condensations to provide a number of diverse heterocyclic structures. The practical utility of this approach to diversity-oriented synthesis (DOS) was further exemplified by its application to the first total synthesis of the isopavine alkaloid roelactamine, which was completed in only four steps from commercially available materials. The application of this methodology towards the synthesis of the Aspidosperma alkaloids rosicine and pseudotabersonine is also presented. To this end, an imine pentadienylation/double RCM strategy has been adopted to rapidly access the pentacyclic core of the aspidospermine alkaloids. This sequence involved the use of a pentadienyl aluminum reagent, which was found to react with aryl imines to give branched products in good yields.

Synthesis of Bioactive Scaffolds

2022-08-22 Science
Download Synthesis of Bioactive Scaffolds PDF Online Free

Author :
Release : 2022-08-22
Genre : Science
Kind : eBook
Book Rating : 461/5 ( reviews)

GET EBOOK


Book Synopsis Synthesis of Bioactive Scaffolds by : Rakesh Kumar Sharma

Download or read book Synthesis of Bioactive Scaffolds written by Rakesh Kumar Sharma. This book was released on 2022-08-22. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-carbon and carbon-heteroatom bond-forming reactions are the backbone of synthetic organic chemistry. Scientists are constantly developing and improving these techniques in order to maximize the diversity of synthetically available molecules. These techniques must be developed in a sustainable manner in order to limit their environmental impact. This book highlights green bond forming reactions for bioactive scaffolds.

Kinetic Control in Synthesis and Self-Assembly

2018-11-23 Science
Download Kinetic Control in Synthesis and Self-Assembly PDF Online Free

Author :
Release : 2018-11-23
Genre : Science
Kind : eBook
Book Rating : 270/5 ( reviews)

GET EBOOK


Book Synopsis Kinetic Control in Synthesis and Self-Assembly by : Munenori Numata

Download or read book Kinetic Control in Synthesis and Self-Assembly written by Munenori Numata. This book was released on 2018-11-23. Available in PDF, EPUB and Kindle. Book excerpt: Kinetic Control in Synthesis and Self-Assembly provides a unique overview of the fundamental principles, novel methods and practical applications for researchers across organic synthesis, supramolecular chemistry and materials sciences. The book examines naturally occurring molecular systems in which kinetic processes are more ubiquitous than thermodynamic processes, also exploring the control of reactions and molecular self-assemblies, through kinetic processes, in artificial systems. These methods currently play a crucial role for tuning materials functions. From organic synthesis, to supramolecular assemblies, and from restricted spaces, to material synthesis for hierarchical structures, the book offers valuable coverage for researchers across disciplines. Interesting topics include how to regulate kinetic pathways more precisely, essential molecular design for kinetic traps, and how molecular environments surrounding molecules (i.e., solvent, temperature, and pressure effects) influence kinetic control in reactions and self-assemblies. - Describes the nature and potential applications of kinetic processes compared to thermodynamic processes - Presents information useful to researchers active in molecular synthesis and self-assembly toward materials - Collates coverage of kinetic control for synthesis and self-assembly, treated separately in literature

You may also like...