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The Resolution Revolution: Recent Advances In cryoEM

2016-08-26 Science
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Release : 2016-08-26
Genre : Science
Kind : eBook
Book Rating : 352/5 ( reviews)

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Book Synopsis The Resolution Revolution: Recent Advances In cryoEM by :

Download or read book The Resolution Revolution: Recent Advances In cryoEM written by . This book was released on 2016-08-26. Available in PDF, EPUB and Kindle. Book excerpt: cryoEM, a new volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods and new developments in recording images, the creation, evaluation and validation of 3D maps from the images, model building into maps and refinement of the resulting atomic structures, and applications of essentially single particle methods to helical structures and to sub-tomogram averaging. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods that determine the structures of biological molecules, a vital step for understanding their function Contains the technical developments underpinning the advances of cryoEM and captures the exciting insights that have resulted

The Resolution Revolution: Recent Advances In CryoEM Methods in Enzymology

2016 Direct Electron
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Release : 2016
Genre : Direct Electron
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis The Resolution Revolution: Recent Advances In CryoEM Methods in Enzymology by : R A. Ed Crowther

Download or read book The Resolution Revolution: Recent Advances In CryoEM Methods in Enzymology written by R A. Ed Crowther. This book was released on 2016. Available in PDF, EPUB and Kindle. Book excerpt:

Single-particle Cryo-electron Microscopy

2017-12-31 Electron microscopy
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Release : 2017-12-31
Genre : Electron microscopy
Kind : eBook
Book Rating : 857/5 ( reviews)

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Book Synopsis Single-particle Cryo-electron Microscopy by : Joachim Frank

Download or read book Single-particle Cryo-electron Microscopy written by Joachim Frank. This book was released on 2017-12-31. Available in PDF, EPUB and Kindle. Book excerpt: The book reproduces 55 of more than 300 articles written by the author, representing milestones in methods development of single-particle cryo-EM as well as important results obtained by this technique in the study of biological macromolecules and their interactions. Importantly, neither symmetries nor ordered arrangements (as in two-dimensional crystals, helical assemblies, icosahedral viruses) are required. Although the biological applications are mainly in the area of ribosome structure and function, the elucidation of membrane channel structures and their activation and gating mechanisms are represented, as well. The book is introduced by a commentary that explains the original development of concepts, describes the contributions of the author's colleagues and students, and shows how challenges were overcome as the technique matured. Along the way, the ribosome served as an example for a macromolecule with intricate structure and conformational dynamics that pose challenges for three-dimensional visualization. Toward the end of the book -- bringing us to the present time -- molecular structures with near-atomic resolution are presented, and a novel type of computational analysis, manifold embedding, is introduced. Single-particle cryo-EM is currently revolutionizing structural biology, presenting a powerful alternative to X-ray crystallography as a means to solve the structure of biological macromolecules. The book presents in one place a number of articles containing key advances in mathematical and computational methods leading up to the present time. Secondly, the development of the technique over the years is reflected by ever-expanding discoveries in the field of ribosome structure and function. Thirdly, as all histories of ideas, the history of concepts pertaining to this new method of visualization is fascinating all in itself.

Advances in Structural Biology

1996-06-21 Science
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Release : 1996-06-21
Genre : Science
Kind : eBook
Book Rating : 500/5 ( reviews)

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Book Synopsis Advances in Structural Biology by : S.K. Malhotra

Download or read book Advances in Structural Biology written by S.K. Malhotra. This book was released on 1996-06-21. Available in PDF, EPUB and Kindle. Book excerpt: The present volume continues the trend established in previous volumes in this series on Advances in Structural Biology. As in the past, diverse topics of current importance relevant to the theme of the series are included in the fourth volume.

Biomolecular and Bioanalytical Techniques

2019-06-10 Science
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Release : 2019-06-10
Genre : Science
Kind : eBook
Book Rating : 964/5 ( reviews)

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Book Synopsis Biomolecular and Bioanalytical Techniques by : Vasudevan Ramesh

Download or read book Biomolecular and Bioanalytical Techniques written by Vasudevan Ramesh. This book was released on 2019-06-10. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide to biomolecular and bioanalytical techniques and their applications Biomolecular and Bioanalytical Techniques offers an introduction to, and a basic understanding of, a wide range of biophysical techniques. The text takes an interdisciplinary approach with contributions from a panel of distinguished experts. With a focus on research, the text comprehensively covers a broad selection of topics drawn from contemporary research in the fields of chemistry and biology. Each of the internationally reputed authors has contributed a single chapter on a specific technique. The chapters cover the specific technique’s background, theory, principles, technique, methodology, protocol and applications. The text explores the use of a variety of analytical tools to characterise biological samples. The contributors explain how to identify and quantify biochemically important molecules, including small molecules as well as biological macromolecules such as enzymes, antibodies, proteins, peptides and nucleic acids. This book is filled with essential knowledge and explores the skills needed to carry out the research and development roles in academic and industrial laboratories. A technique-focused book that bridges the gap between an introductory text and a book on advanced research methods Provides the necessary background and skills needed to advance the research methods Features a structured approach within each chapter Demonstrates an interdisciplinary approach that serves to develop independent thinking Written for students in chemistry, biological, medical, pharmaceutical, forensic and biophysical sciences, Biomolecular and Bioanalytical Techniques is an in-depth review of the most current biomolecular and bioanalytical techniques in the field.

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