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The Postmortem Brain in Psychiatric Research

2013-03-09 Psychology
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Release : 2013-03-09
Genre : Psychology
Kind : eBook
Book Rating : 312/5 ( reviews)

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Book Synopsis The Postmortem Brain in Psychiatric Research by : Galila Agam

Download or read book The Postmortem Brain in Psychiatric Research written by Galila Agam. This book was released on 2013-03-09. Available in PDF, EPUB and Kindle. Book excerpt: Because of the dearth of experimental animal models of psychiatric disorders, the study of the effect of the disease state is only possible in tissue derived from patients vs. controls, especially in the target tissue of disease-related changes in the brain. The human postmortem brain offers the most appropriate experimental paradigm towards understanding the etiology of psychiatric disorders. The availability of post-mortem human samples from psychiatric patients and comparison groups in recent years has contributed prominently to the accumulating body of information leading to a better understanding of these disorders. This is the first book to summarize this research approach and the meaningful data which has recently been acquired.

Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide

2019-02-13 Medical
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Release : 2019-02-13
Genre : Medical
Kind : eBook
Book Rating : 417/5 ( reviews)

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Book Synopsis Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide by : Brian Dean

Download or read book Using CNS Autopsy Tissue in Psychiatric Research: A Practical Guide written by Brian Dean. This book was released on 2019-02-13. Available in PDF, EPUB and Kindle. Book excerpt: Essential for the laboratory, this practical manual presents a wide variety of techniques associated with the use of human CNS tissue obtained at autopsy. The book contains detailed methodologies in discrete chapters written by an expert in the specific field. It also addresses the potential for extending molecular studies in brain tissue obtain

Molecular Neuropathology

1995-06-08 Medical
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Release : 1995-06-08
Genre : Medical
Kind : eBook
Book Rating : 582/5 ( reviews)

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Book Synopsis Molecular Neuropathology by : Gareth W. Roberts

Download or read book Molecular Neuropathology written by Gareth W. Roberts. This book was released on 1995-06-08. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an introduction to the essential techniques required for studying the molecular biology of brain disease. The approaches and strategies for investigations of gene structure and regulation are described with reference to the molecular genetics of prion and Alzheimer's disease. The effects of aberrant gene regulation can also be examined at the protein level by immunocytochemistry and autoradiography. Improved understanding of basic biology has resulted in new approaches to animal models using transgenic techniques and new therapeutic approaches. The volume is structured to illustrate all these approaches and demonstrate the practice and promise of molecular neuropathology.

Brain Banking

2018-02-27 Medical
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Release : 2018-02-27
Genre : Medical
Kind : eBook
Book Rating : 420/5 ( reviews)

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Book Synopsis Brain Banking by :

Download or read book Brain Banking written by . This book was released on 2018-02-27. Available in PDF, EPUB and Kindle. Book excerpt: Brain Banking, Volume 150, serves as the only book on the market offering comprehensive coverage of the functional realities of brain banking. It focuses on brain donor recruitment strategies, brain bank networks, ethical issues, brain dissection/tissue processing/tissue dissemination, neuropathological diagnosis, brain donor data, and techniques in brain tissue analysis. In accordance with massive initiatives, such as BRAIN and the EU Human Brain Project, abnormalities and potential therapeutic targets of neurological and psychiatric disorders need to be validated in human brain tissue, thus requiring substantial numbers of well characterized human brains of high tissue quality with neurological and psychiatric diseases. - Offers comprehensive coverage of the functional realities of brain banking, with a focus on brain donor recruitment strategies, brain bank networks, ethical issues, and more - Serves as a valuable resource for staff in existing brain banks by highlighting best practices - Enhances the sharing of expertise between existing banks and highlights a range of techniques applicable to banked tissue for neuroscience researchers - Authored by leaders from brain banks around the globe – the broadest, most expert coverage available

The Neurobiological Basis of Suicide

2012-06-25 Medical
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Release : 2012-06-25
Genre : Medical
Kind : eBook
Book Rating : 81X/5 ( reviews)

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Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi

Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi. This book was released on 2012-06-25. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

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