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The Genetics and Development of Scoliosis

2009-12-15 Medical
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Release : 2009-12-15
Genre : Medical
Kind : eBook
Book Rating : 064/5 ( reviews)

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Book Synopsis The Genetics and Development of Scoliosis by : Kenro Kusumi

Download or read book The Genetics and Development of Scoliosis written by Kenro Kusumi. This book was released on 2009-12-15. Available in PDF, EPUB and Kindle. Book excerpt: Developmental genetic studies of the spine and linkage and family-based association studies have led to recent advances in understanding the genetic etiology of idiopathic, neuromuscular, and congenital forms of scoliosis. The book is written by leaders in genetic and developmental research on scoliosis and developmental studies of the spine.

Pathogenesis of Idiopathic Scoliosis

2018-02-23 Medical
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Release : 2018-02-23
Genre : Medical
Kind : eBook
Book Rating : 418/5 ( reviews)

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Book Synopsis Pathogenesis of Idiopathic Scoliosis by : Masafumi Machida

Download or read book Pathogenesis of Idiopathic Scoliosis written by Masafumi Machida. This book was released on 2018-02-23. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive coverage of current topics in idiopathic scoliosis (IS). A three-dimensional deformity of the spine, the condition is characterized by lateral curvature combined with vertebral rotation. The primary lesion, however, lies in the median sagittal plane, taking the form of a lordosis. Although the clinical manifestations of scoliosis have been well documented, its cause and pathogenesis have not yet been determined. Research into what causes IS has focused on the structural elements of the spine, spinal musculature, collagenous structures, the endocrine system, the central nervous system, and genetics. Results of these studies have brought about a new perception of IS epiphenomena, but the main cause of IS remains unknown. Recently, several investigators have produced new hypotheses regarding the cause of IS using the developing techniques of genetics, biochemistry, and neurology. This book is a review of the various causative factors thus far proposed for IS and an introduction to the directions in which research is heading to determine the primary cause of IS.

Molecular Genetics of Pediatric Orthopaedic Disorders

2015-03-04 Medical
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Release : 2015-03-04
Genre : Medical
Kind : eBook
Book Rating : 69X/5 ( reviews)

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Book Synopsis Molecular Genetics of Pediatric Orthopaedic Disorders by : Carol A. Wise

Download or read book Molecular Genetics of Pediatric Orthopaedic Disorders written by Carol A. Wise. This book was released on 2015-03-04. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades we have seen a surge forward in understanding the genetics and biochemistry underlying many pediatric orthopaedic disorders. A few projects have even progressed into the realm of clinical trials that are primarily aimed at controlling progressive disease. Meanwhile, genomic technology development has outpaced expectations and is enabling gene discovery for disorders that were previously intractable with traditional genetic methods. Included in this latter category are common disorders that display multigenic inheritance, sporadic disorders, and very rare conditions that are difficult to ascertain. Simultaneously, the study of pediatric orthopaedic disorders has been continuously refined and updated, highlighting a number of likely genetic conditions that are as yet unsolved. Molecular Genetics of Pediatric Orthopaedic Disorders updates researchers and clinicians of new developments of pediatric orthopaedic genetics. The chapters inform the audience on the revolution in new genomic methods and the impact this is having on potential study designs and the potential to discover genetic causes of many unsolved orthopaedic conditions. Recent examples have been included of pediatric orthopaedic conditions, both rare and common, that are being solved with these new methods. The book also educates pediatric orthopedic clinicians and geneticists on our understanding of the biology of “classic” genetic diseases that were derived from prior genetic studies. Chapters include biobanks and strategies for studying very rare disorders, genes and pathways causing primordial dwarfism, and notch signaling in congenital scoliosis, and more.​

Adolescent Idiopathic Scoliosis

2004 Scoliosis
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Release : 2004
Genre : Scoliosis
Kind : eBook
Book Rating : 331/5 ( reviews)

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Book Synopsis Adolescent Idiopathic Scoliosis by : Peter O. Newton

Download or read book Adolescent Idiopathic Scoliosis written by Peter O. Newton. This book was released on 2004. Available in PDF, EPUB and Kindle. Book excerpt: Covers the anatomy, etiology, and natural history of scoliosis - from patient evaluation and an algorithm for treatment to pulmonary function after surgical treatment and the use of instruments to evaluate surgical treatment. This new monograph focuses on the most common form of scoliosis occurring otherwise normal adolescents, affecting spinal alignment, growth, and function.

Disordered Vertebral and Rib Morphology in Pudgy Mice

2016-09-30 Medical
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Release : 2016-09-30
Genre : Medical
Kind : eBook
Book Rating : 499/5 ( reviews)

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Book Synopsis Disordered Vertebral and Rib Morphology in Pudgy Mice by : Frederic Shapiro

Download or read book Disordered Vertebral and Rib Morphology in Pudgy Mice written by Frederic Shapiro. This book was released on 2016-09-30. Available in PDF, EPUB and Kindle. Book excerpt: ​This book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself.

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