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The Adenoviruses

2013-03-08 Medical
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Release : 2013-03-08
Genre : Medical
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Book Rating : 350/5 ( reviews)

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Book Synopsis The Adenoviruses by : Harold S. Ginsberg

Download or read book The Adenoviruses written by Harold S. Ginsberg. This book was released on 2013-03-08. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .

Therapeutic Applications of Adenoviruses

2016-12-12 Medical
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Release : 2016-12-12
Genre : Medical
Kind : eBook
Book Rating : 803/5 ( reviews)

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Book Synopsis Therapeutic Applications of Adenoviruses by : Philip Ng

Download or read book Therapeutic Applications of Adenoviruses written by Philip Ng. This book was released on 2016-12-12. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviruses are double stranded DNA viruses that have been used to study the process of DNA replication. Studies of the mode of action of adenovirally produced tumors in rodents led to the discovery of tumour supressor genes. The adenoviral vector is now the most used vector in clinical gene therapy especially for some kinds of cancers. The chapters in this book focus on the most up-to-date developments in the therapeutic applications of adenoviruses. The intended audience is individuals in the Life Sciences interested in therapeutic applications of adenoviruses. This book reviews the life history and immune responses to adenoviruses and summarizes various therapies implemented with the use of adenoviruses.

Adenoviral Vectors for Gene Therapy

2016-03-10 Science
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Release : 2016-03-10
Genre : Science
Kind : eBook
Book Rating : 106/5 ( reviews)

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Book Synopsis Adenoviral Vectors for Gene Therapy by : David T. Curiel

Download or read book Adenoviral Vectors for Gene Therapy written by David T. Curiel. This book was released on 2016-03-10. Available in PDF, EPUB and Kindle. Book excerpt: Adenoviral Vectors for Gene Therapy, Second Edition provides detailed, comprehensive coverage of the gene delivery vehicles that are based on the adenovirus that is emerging as an important tool in gene therapy. These exciting new therapeutic agents have great potential for the treatment of disease, making gene therapy a fast-growing field for research. This book presents topics ranging from the basic biology of adenoviruses, through the construction and purification of adenoviral vectors, cutting-edge vectorology, and the use of adenoviral vectors in preclinical animal models, with final consideration of the regulatory issues surrounding human clinical gene therapy trials. This broad scope of information provides a solid overview of the field, allowing the reader to gain a complete understanding of the development and use of adenoviral vectors. Provides complete coverage of the basic biology of adenoviruses, as well as their construction, propagation, and purification of adenoviral vectors Introduces common strategies for the development of adenoviral vectors, along with cutting-edge methods for their improvement Demonstrates noninvasive imaging of adenovirus-mediated gene transfer Discusses utility of adenoviral vectors in animal disease models Considers Federal Drug Administration regulations for human clinical trials

Laboratory Diagnosis of Infectious Diseases Principles and Practice

2012-12-06 Medical
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Release : 2012-12-06
Genre : Medical
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Book Rating : 001/5 ( reviews)

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Book Synopsis Laboratory Diagnosis of Infectious Diseases Principles and Practice by : Edwin H. Lennette

Download or read book Laboratory Diagnosis of Infectious Diseases Principles and Practice written by Edwin H. Lennette. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt: those who deal with infectious diseases on a daily This two volume work stems from the belief of the Editors that infectious diseases are not only very basis. much with us today but, more importantly, that they There are several excellent textbooks dealing will continue to playa significant global role in mor with medical microbiology, and there are equally bidity and mortality in all people. A continuing need well-recognized books devoted to infectious dis for an informed and knowledgeable community of eases. The Editors of this work, on the other hand, were persuaded that there was a need for a publica laboratory scientists is fundamental. Data describing tion that would bring together the most pertinent and the global impact of infectious diseases are difficult to come by. Fortunately, a recent thoughtful and relevant information on the principles and practice of provocative publication by Bennett et al. (1987) pro the laboratory diagnosis of infectious diseases and vides us with data derived from several consultants include clinical relationships. While this two volume that clearly delineate the impact of infectious dis text is directed toward the role of the laboratory in eases on the United States today.

The Adenoviruses

2014-01-15
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Release : 2014-01-15
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Book Rating : 362/5 ( reviews)

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Book Synopsis The Adenoviruses by : Harold S Ginsberg

Download or read book The Adenoviruses written by Harold S Ginsberg. This book was released on 2014-01-15. Available in PDF, EPUB and Kindle. Book excerpt:

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