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Author : Jingyan Li
Release : 2012
Genre :
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Surface-modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons by : Jingyan Li
Download or read book Surface-modified PLGA Nanoparticles for Targeted Drug Delivery to Neurons written by Jingyan Li. This book was released on 2012. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yashwant V Pathak
Release : 2019-03-11
Genre : Medical
Kind : eBook
Book Rating : 159/5 ( reviews)
Book Synopsis Surface Modification of Nanoparticles for Targeted Drug Delivery by : Yashwant V Pathak
Download or read book Surface Modification of Nanoparticles for Targeted Drug Delivery written by Yashwant V Pathak. This book was released on 2019-03-11. Available in PDF, EPUB and Kindle. Book excerpt: This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.
Author : Maria Carmo Pereira
Release : 2021-03-01
Genre : Science
Kind : eBook
Book Rating : 203/5 ( reviews)
Book Synopsis PLGA Based Drug Carrier and Pharmaceutical Applications by : Maria Carmo Pereira
Download or read book PLGA Based Drug Carrier and Pharmaceutical Applications written by Maria Carmo Pereira. This book was released on 2021-03-01. Available in PDF, EPUB and Kindle. Book excerpt: Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.
Author : Fangchao Liu
Release : 2019
Genre : Chemical engineering
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis Engineering of Gold Nanoparticles for Targeted Drug Delivery by : Fangchao Liu
Download or read book Engineering of Gold Nanoparticles for Targeted Drug Delivery written by Fangchao Liu. This book was released on 2019. Available in PDF, EPUB and Kindle. Book excerpt: Due to their ease of synthesis, versatile surface chemistry, ease of imaging, and biocompatibility, gold nanoparticles (AuNPs) are employed as drug delivery devices in the treatment of respiratory problems associated with spinal cord injury (SCI). We have developed a method for the synthesis of a tripartite nanoconjugate comprised of an AuNP drug carrier chemically conjugated to a transporter protein (wheat germ agglutinin coupled to horseradish peroxidase or WGA-HRP) and to potent SCI drugs. The therapeutic efficacy and biodistribution were studied in a validated animal model. Our results show that a single administration of the nanoconjugate improved diaphragmatic activity at a much lower dosage than the effective systemic drug dosage and restored the respiratory drive. The effects lasted for 4 weeks. A biodistribution study using inductively coupled plasma mass spectrometry on the same animal model shows that the nanoconjugate was successful in targeting the respiratory neurons in the medulla by detecting the presence of gold in the medulla and spinal cord. The AuNPs are also applied in triple negative breast cancer treatment. By conjugating the surface modified AuNPs with a non-soluble drug, the solubility has been increased and introduced cancer cell death after administration. The nanoconjugate structure was determined by UV-vis spectroscopy, transmission electron microscopy, dynamic light scattering, thermogravimetric analysis, and mass spectrometry.
Author : Mohammed Abdulhussein Handooz Albarki
Release : 2016
Genre : Intranasal medication
Kind : eBook
Book Rating : /5 ( reviews)
Book Synopsis In Vitro Assessment of the Transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Across the Nasal Mucosa by : Mohammed Abdulhussein Handooz Albarki
Download or read book In Vitro Assessment of the Transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Across the Nasal Mucosa written by Mohammed Abdulhussein Handooz Albarki. This book was released on 2016. Available in PDF, EPUB and Kindle. Book excerpt: The nasal mucosa provides a rapid, noninvasive route for drug administration to the systemic circulation and even potentially to the CNS. Nanoparticles made from the biodegradable polymer, PLGA, are of great interest for use in drug delivery systems due to PLGA's relative safety and ease of surface modification. Nanoparticles may provide improved targeting and transport through the nasal mucosa. However, the optimal nanoparticle sizes and surface properties for intranasal delivery are unknown. In this study, we prepared PLGA nanoparticles within a size range of 50-70 nm containing the lipophilic fluorescent dye, Nile Red, using a surfactant-free nanoprecipitation method. The resulting nanoparticles were evaluated using dynamic light scattering and scanning electron microscopy. Nanoparticle uptake into the nasal mucosa was determined by exposing the tissues to nanoparticle dispersions for 30 or 60 minutes. The in vitro uptake of the nanoparticles by the nasal mucosal tissues revealed that the Nile Red-loaded PLGA nanoparticles were transported across the epithelial layer and accumulated in the sub-mucosal connective tissues. Nanoparticle uptake in the full thickness tissues was time dependent where 2% of the total loads of nanoparticles exposed to the tissues were measured in the mucosal tissue after 30 minutes and 4% were present in the tissues after 60 minutes. The rapid and measurable transfer of PLGA nanoparticles into the nasal mucosal tissues indicate that they may be an efficient delivery vehicle for drugs with either local or systemic activities.
