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In Vitro Assessment of the Transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Across the Nasal Mucosa

2016 Intranasal medication
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Release : 2016
Genre : Intranasal medication
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Book Synopsis In Vitro Assessment of the Transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Across the Nasal Mucosa by : Mohammed Abdulhussein Handooz Albarki

Download or read book In Vitro Assessment of the Transport of Poly D, L Lactic-Co-Glycolic Acid (PLGA) Nanoparticles Across the Nasal Mucosa written by Mohammed Abdulhussein Handooz Albarki. This book was released on 2016. Available in PDF, EPUB and Kindle. Book excerpt: The nasal mucosa provides a rapid, noninvasive route for drug administration to the systemic circulation and even potentially to the CNS. Nanoparticles made from the biodegradable polymer, PLGA, are of great interest for use in drug delivery systems due to PLGA's relative safety and ease of surface modification. Nanoparticles may provide improved targeting and transport through the nasal mucosa. However, the optimal nanoparticle sizes and surface properties for intranasal delivery are unknown. In this study, we prepared PLGA nanoparticles within a size range of 50-70 nm containing the lipophilic fluorescent dye, Nile Red, using a surfactant-free nanoprecipitation method. The resulting nanoparticles were evaluated using dynamic light scattering and scanning electron microscopy. Nanoparticle uptake into the nasal mucosa was determined by exposing the tissues to nanoparticle dispersions for 30 or 60 minutes. The in vitro uptake of the nanoparticles by the nasal mucosal tissues revealed that the Nile Red-loaded PLGA nanoparticles were transported across the epithelial layer and accumulated in the sub-mucosal connective tissues. Nanoparticle uptake in the full thickness tissues was time dependent where 2% of the total loads of nanoparticles exposed to the tissues were measured in the mucosal tissue after 30 minutes and 4% were present in the tissues after 60 minutes. The rapid and measurable transfer of PLGA nanoparticles into the nasal mucosal tissues indicate that they may be an efficient delivery vehicle for drugs with either local or systemic activities.

Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery

2023-03-02 Technology & Engineering
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Release : 2023-03-02
Genre : Technology & Engineering
Kind : eBook
Book Rating : 314/5 ( reviews)

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Book Synopsis Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery by : Prashant Kesharwani

Download or read book Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery written by Prashant Kesharwani. This book was released on 2023-03-02. Available in PDF, EPUB and Kindle. Book excerpt: Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail. The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials. Presents the fundamentals of PLGA nanoparticles, including properties, preparation, characterization, and biofate and cellular interactions Provides in-depth coverage of a broad range of specific applications of PLGA nanoparticles across disease treatment, regenerative medicine and therapeutic areas Offers a methodical approach to PLGA nanoparticles in drug delivery that is supported by data tables, illustrative figures and flowcharts

Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury

2021
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Release : 2021
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Book Synopsis Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury by : Katherine Mackenzie North

Download or read book Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury written by Katherine Mackenzie North. This book was released on 2021. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) presents a serious challenge for modern medicine due to the poor regenerative capabilities of the brain, complex pathophysiology, and lack of effective treatment for TBI to date. The overall goal of this research is to develop as nanoparticle capable of sustained drug release for the delivery and treatment of TBI so that therapeutic drug can be delivered after the Blood Brain Barrier (BBB) closes 24 hours after injury. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles have shown some experimental success; as of yet, none have yielded improved results of clinical efficacy. Polyethylene Glycol (PEG) has been shown to act as a stealth molecule that can increase the circulation time of particles. N-acetylcysteine has shown neuroprotective and anti-inflammatory potential. This paper presents the development of PEGylated PLGA NPs synthesized using double and single emulsion for potential therapeutic delivery to TBI. Dynamic light scattering (DLS) show PEG-PLGA NPs to have an average diameter of 200 nm. Loading capacity was obtained at 2%, and drug encapsulation efficiency was obtained at 55%. A biphasic drug release pattern was noted in situ and drug release was assessed in vitro over 72 h using FRET nanoparticles, almost complete release of drug was seen during this time period. Finally, in vivo administration of PEG-PLGA NPs demonstrated that PEGylated NPS were able to show reduced accumulation in filtration organs such as the liver and kidneys compared to bare PLGA particles. This evidence supports the potential of PEG-PLGA NPs as a promising carrier to develop TBI therapeutics.

The Blood Brain Barrier (BBB)

2014-10-24 Science
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Release : 2014-10-24
Genre : Science
Kind : eBook
Book Rating : 872/5 ( reviews)

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Book Synopsis The Blood Brain Barrier (BBB) by : Gert Fricker

Download or read book The Blood Brain Barrier (BBB) written by Gert Fricker. This book was released on 2014-10-24. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Environmentally Degradable Materials Based on Multicomponent Polymeric Systems

2009-12-21 Technology & Engineering
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Release : 2009-12-21
Genre : Technology & Engineering
Kind : eBook
Book Rating : 103/5 ( reviews)

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Book Synopsis Environmentally Degradable Materials Based on Multicomponent Polymeric Systems by : Cornelia Vasile

Download or read book Environmentally Degradable Materials Based on Multicomponent Polymeric Systems written by Cornelia Vasile. This book was released on 2009-12-21. Available in PDF, EPUB and Kindle. Book excerpt: Environmentally Degradable Materials (EDPs) should replace petroleum-based plastics where recycling is not viable for logistic or labor cost reason. This book discusses the general background of obtaining such systems, compatibilization methodologies, control of the rate of degradation and final products after degradation, life time assessment, toxicological aspects, applications and market aspects. This book is a complete guide to the subject of biodegradable materials based on multi-component polymeric systems, mainly such as hydrogels, and interpenetrating polymeric networks. This book is a complete guide to the subject of biodegradable materials based on multicomponent polymeric systems such as mainly hydrogels, interpenetrating polymeric networks.

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