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Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery

2023-03-02 Technology & Engineering
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Release : 2023-03-02
Genre : Technology & Engineering
Kind : eBook
Book Rating : 314/5 ( reviews)

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Book Synopsis Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery by : Prashant Kesharwani

Download or read book Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery written by Prashant Kesharwani. This book was released on 2023-03-02. Available in PDF, EPUB and Kindle. Book excerpt: Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail. The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials. Presents the fundamentals of PLGA nanoparticles, including properties, preparation, characterization, and biofate and cellular interactions Provides in-depth coverage of a broad range of specific applications of PLGA nanoparticles across disease treatment, regenerative medicine and therapeutic areas Offers a methodical approach to PLGA nanoparticles in drug delivery that is supported by data tables, illustrative figures and flowcharts

PLGA Based Drug Carrier and Pharmaceutical Applications

2021-03-01 Science
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Release : 2021-03-01
Genre : Science
Kind : eBook
Book Rating : 203/5 ( reviews)

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Book Synopsis PLGA Based Drug Carrier and Pharmaceutical Applications by : Maria Carmo Pereira

Download or read book PLGA Based Drug Carrier and Pharmaceutical Applications written by Maria Carmo Pereira. This book was released on 2021-03-01. Available in PDF, EPUB and Kindle. Book excerpt: Poly(lactic-co-glycolic acid) (PLGA) is one of the most successful polymers used for producing therapeutic devices, such as drug carriers (DC). PLGA is one of the few polymers that the Food and Drug Administration (FDA) has approved for human administration due to its biocompatibility and biodegradability. In recent years, DC produced with PLGA has gained enormous attention for its versatility in transporting different type of drugs, e.g., hydrophilic or hydrophobic small molecules, or macromolecules with a controlled drug release without modifying the physiochemical properties of the drugs. These drug delivery systems have the possibility/potential to modify their surface properties with functional groups, peptides, or other coatings to improve the interactions with biological materials. Furthermore, they present the possibility to be conjugated with specific target molecules to reach specific tissues or cells. They are also used for different therapeutic applications, such as in vaccinations, cancer treatment, neurological disorder treatment, and as anti-inflammatory agents. This book aims to focus on the recent progress of PLGA as a drug carrier and their new pharmaceutical applications.

7th Asian-Pacific Conference on Medical and Biological Engineering

2008-05-17 Technology & Engineering
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Release : 2008-05-17
Genre : Technology & Engineering
Kind : eBook
Book Rating : 39X/5 ( reviews)

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Book Synopsis 7th Asian-Pacific Conference on Medical and Biological Engineering by : Yi Peng

Download or read book 7th Asian-Pacific Conference on Medical and Biological Engineering written by Yi Peng. This book was released on 2008-05-17. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the proceedings of the 7th Asian-Pacific Conference on Medical and Biological Engineering (APCMBE 2008). Themed "Biomedical Engineering – Promoting Sustainable Development of Modern Medicine" the proceedings address a broad spectrum of topics from Bioengineering and Biomedicine, like Biomaterials, Artificial Organs, Tissue Engineering, Nanobiotechnology and Nanomedicine, Biomedical Imaging, Bio MEMS, Biosignal Processing, Digital Medicine, BME Education. It helps medical and biological engineering professionals to interact and exchange their ideas and experiences.

Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury

2021
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Release : 2021
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Book Rating : /5 ( reviews)

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Book Synopsis Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury by : Katherine Mackenzie North

Download or read book Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanoparticles for Therapeutic Delivery to Traumatic Brain Injury written by Katherine Mackenzie North. This book was released on 2021. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) presents a serious challenge for modern medicine due to the poor regenerative capabilities of the brain, complex pathophysiology, and lack of effective treatment for TBI to date. The overall goal of this research is to develop as nanoparticle capable of sustained drug release for the delivery and treatment of TBI so that therapeutic drug can be delivered after the Blood Brain Barrier (BBB) closes 24 hours after injury. Poly(lactic-co-glycolic acid) (PLGA) nanoparticles have shown some experimental success; as of yet, none have yielded improved results of clinical efficacy. Polyethylene Glycol (PEG) has been shown to act as a stealth molecule that can increase the circulation time of particles. N-acetylcysteine has shown neuroprotective and anti-inflammatory potential. This paper presents the development of PEGylated PLGA NPs synthesized using double and single emulsion for potential therapeutic delivery to TBI. Dynamic light scattering (DLS) show PEG-PLGA NPs to have an average diameter of 200 nm. Loading capacity was obtained at 2%, and drug encapsulation efficiency was obtained at 55%. A biphasic drug release pattern was noted in situ and drug release was assessed in vitro over 72 h using FRET nanoparticles, almost complete release of drug was seen during this time period. Finally, in vivo administration of PEG-PLGA NPs demonstrated that PEGylated NPS were able to show reduced accumulation in filtration organs such as the liver and kidneys compared to bare PLGA particles. This evidence supports the potential of PEG-PLGA NPs as a promising carrier to develop TBI therapeutics.

Bio-inspired Polymers

2016-10-14 Science
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Release : 2016-10-14
Genre : Science
Kind : eBook
Book Rating : 662/5 ( reviews)

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Book Synopsis Bio-inspired Polymers by : Nico Bruns

Download or read book Bio-inspired Polymers written by Nico Bruns. This book was released on 2016-10-14. Available in PDF, EPUB and Kindle. Book excerpt: Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

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