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Pharmacokinetics and Metabolism in Drug Design

2012-05-14 Medical
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Release : 2012-05-14
Genre : Medical
Kind : eBook
Book Rating : 544/5 ( reviews)

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Book Synopsis Pharmacokinetics and Metabolism in Drug Design by : Dennis A. Smith

Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith. This book was released on 2012-05-14. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

Pharmacokinetics and Metabolism in Drug Design

2006-08-21 Medical
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Release : 2006-08-21
Genre : Medical
Kind : eBook
Book Rating : 281/5 ( reviews)

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Book Synopsis Pharmacokinetics and Metabolism in Drug Design by : Dennis A. Smith

Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith. This book was released on 2006-08-21. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Pharmacokinetics and Metabolism in Drug Design, Volume 13

2001 Medical
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Release : 2001
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Pharmacokinetics and Metabolism in Drug Design, Volume 13 by : Dennis A. Smith

Download or read book Pharmacokinetics and Metabolism in Drug Design, Volume 13 written by Dennis A. Smith. This book was released on 2001. Available in PDF, EPUB and Kindle. Book excerpt: The medical benefits of a drug are not only dependent on its biological effect, but also on its "life cycle" within the organism - from its absorption into the blood, distribution to tissue until its eventual breakdown or excretion by the liver and kidneys. This book explains in readily comprehensible terms the problems that may arise, and how these may be taken into account at an early stage in drug development.

Drug Metabolism and Pharmacokinetics Quick Guide

2011-04-07 Medical
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Release : 2011-04-07
Genre : Medical
Kind : eBook
Book Rating : 298/5 ( reviews)

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Book Synopsis Drug Metabolism and Pharmacokinetics Quick Guide by : Siamak Cyrus Khojasteh

Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh. This book was released on 2011-04-07. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Drug Metabolism in Drug Design and Development

2007-11-16 Science
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Release : 2007-11-16
Genre : Science
Kind : eBook
Book Rating : 682/5 ( reviews)

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Book Synopsis Drug Metabolism in Drug Design and Development by : Donglu Zhang

Download or read book Drug Metabolism in Drug Design and Development written by Donglu Zhang. This book was released on 2007-11-16. Available in PDF, EPUB and Kindle. Book excerpt: The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.

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