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Drug Metabolism and Pharmacokinetics Quick Guide

2011-04-07 Medical
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Release : 2011-04-07
Genre : Medical
Kind : eBook
Book Rating : 298/5 ( reviews)

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Book Synopsis Drug Metabolism and Pharmacokinetics Quick Guide by : Siamak Cyrus Khojasteh

Download or read book Drug Metabolism and Pharmacokinetics Quick Guide written by Siamak Cyrus Khojasteh. This book was released on 2011-04-07. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.

Discovery DMPK Quick Guide

2022
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Release : 2022
Genre :
Kind : eBook
Book Rating : 927/5 ( reviews)

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Book Synopsis Discovery DMPK Quick Guide by : S. Cyrus Khojasteh

Download or read book Discovery DMPK Quick Guide written by S. Cyrus Khojasteh. This book was released on 2022. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics, and toxicology. It provides, for the first time, a completely integrated look at multiple aspects of ADME sciences (absorption, distribution, metabolism, and excretion) in a summary format that is clear, concise, and self-explanatory. DMPK in Drug Discovery - Guide to Data Interpretation and integration leverages the prior knowledge from the first book that covers the basics of each concept (Drug Metabolism and Pharmacokinetics Quick Guide). This reference book is meant to be used day to day and provides many useful tables (used for data interpretation), figures, and case studies that can facilitate drug discovery. The case studies are intended to be short and relevant to the topic discussed and present another dimension to the discussions.

Pocket Guide to Drug Metabolism and Pharmacokinetics

1996
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Release : 1996
Genre :
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Pocket Guide to Drug Metabolism and Pharmacokinetics by : David G. Walker

Download or read book Pocket Guide to Drug Metabolism and Pharmacokinetics written by David G. Walker. This book was released on 1996. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacokinetics and Metabolism in Drug Design

2006-08-21 Medical
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Release : 2006-08-21
Genre : Medical
Kind : eBook
Book Rating : 281/5 ( reviews)

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Book Synopsis Pharmacokinetics and Metabolism in Drug Design by : Dennis A. Smith

Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith. This book was released on 2006-08-21. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been updated and new material has been added, especially in the areas of toxicity testing and high throughput analysis. The authors, all of them employed at Pfizer in the discovery and development of new active substances, discuss the significant parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. They cover everything from the fundamental principles right up to the impact of pharmacokinetic parameters on the discovery of new drugs. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects.

Pharmacokinetics and Metabolism in Drug Design

2012-09-13 Medical
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Release : 2012-09-13
Genre : Medical
Kind : eBook
Book Rating : 292/5 ( reviews)

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Book Synopsis Pharmacokinetics and Metabolism in Drug Design by : Dennis A. Smith

Download or read book Pharmacokinetics and Metabolism in Drug Design written by Dennis A. Smith. This book was released on 2012-09-13. Available in PDF, EPUB and Kindle. Book excerpt: In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.

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