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PH and Brain Function

1998-09-15 Medical
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Release : 1998-09-15
Genre : Medical
Kind : eBook
Book Rating : 381/5 ( reviews)

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Book Synopsis PH and Brain Function by : Kai Kaila

Download or read book PH and Brain Function written by Kai Kaila. This book was released on 1998-09-15. Available in PDF, EPUB and Kindle. Book excerpt: "PH and Brain Function offers thorough coverage of this increasingly important area of research, beginning with the fundamental concepts, which include methodological and theoretical issues such as the measurement of pH and the concept of pH in neurobiology. It explores aspects of regulation and modulation of intracellular pH in brain cells, surveys the changes in pH that occur with neural activity and how these changes affect neural activity, and discusses the role of pH in the pathophysiology of neurological diseases." "pH and Brain Function is an important resource for researchers in all areas of neuroscience as well as cell biology and physiology." --Book Jacket.

Detecting Activity-evoked PH Changes in Human Brain

2013 Brain
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Release : 2013
Genre : Brain
Kind : eBook
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Book Synopsis Detecting Activity-evoked PH Changes in Human Brain by : Hye Young Heo

Download or read book Detecting Activity-evoked PH Changes in Human Brain written by Hye Young Heo. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Localized pH changes have been suggested to occur in the brain during normal function. However, a lack of methods for non-invasively measuring pH with high spatial and temporal resolution limits current knowledge of brain pH dynamics. Here I report that a magnetic resonance imaging (MRI) strategy named T1 relaxation in the rotating frame (T1[rho]) is sufficiently sensitive to detect widespread pH changes in the mouse and human brain evoked by systemically manipulating carbon dioxide (CO2) or bicarbonate (HCO3). Moreover, T1[rho] detected changes suggesting a localized acidosis in the human visual cortex induced by a flashing checkerboard. Lactate measurements and pH-sensitive 31P spectroscopy at the same site also suggest a localized acidosis. Consistent with the established role for pH in blood flow recruitment, T1[rho] correlated with blood oxygenation level dependent contrast (BOLD), although T1[rho] was directly sensitive to blood oxygen content. These observations provide the strongest evidence thus far for localized pH fluctuations in the human brain during normal function ...

Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications

2013-10-22 Medical
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Release : 2013-10-22
Genre : Medical
Kind : eBook
Book Rating : 595/5 ( reviews)

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Book Synopsis Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications by : Susan C. Frost

Download or read book Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications written by Susan C. Frost. This book was released on 2013-10-22. Available in PDF, EPUB and Kindle. Book excerpt: The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is part of the carboxysome shell perhaps supplying RuBisCO with CO2 for carbon fixation. With the excitement surrounding the discovery of disease-related CAs, scientists have redoubled their efforts to better understand structure-function relationships, to design high affinity, isotype-specific inhibitors, and to delineate signaling systems that play regulatory roles over expression and activity. We have designed the book to cover basic information of mechanism, structure, and function of the CA families. The authors included in this book bring to light the newest data with regard to the role of CA in physiology and pathology, across phylums, and in unique environmental niches.

Brain Function and Metabolic Disorders

1963 Biochemistry
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Release : 1963
Genre : Biochemistry
Kind : eBook
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Book Synopsis Brain Function and Metabolic Disorders by : Barry Wyke

Download or read book Brain Function and Metabolic Disorders written by Barry Wyke. This book was released on 1963. Available in PDF, EPUB and Kindle. Book excerpt:

Supercharge Your Brain

2022-01-04 Science
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Release : 2022-01-04
Genre : Science
Kind : eBook
Book Rating : 685/5 ( reviews)

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Book Synopsis Supercharge Your Brain by : James Goodwin

Download or read book Supercharge Your Brain written by James Goodwin. This book was released on 2022-01-04. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to keeping your brain healthy for a long and lucid life, by one of the world's leading scientists in the field of brain health and ageing. The brain is our most vital and complex organ. It controls and coordinates our actions, thoughts and interactions with the world around us. It is the source of personality, of our sense of self, and it shapes every aspect of our human experience. Yet most of us know precious little about how our brains actually work, or what we can do to optimise their performance. Whilst cognitive decline is the biggest long-term health worry for many of us, practical knowledge of how to look after our brain is thin on the ground. In this ground-breaking new book, leading expert Professor James Goodwin explains how simple strategies concerning exercise, diet, social life, and sleep can transform your brain health paradigm, and shows how you can keep your brain youthful and stay sharp across your life. Combining the latest scientific research with insightful storytelling and practical advice, Supercharge Your Brain reveals everything you need to know about how your brain functions, and what you can do to keep it in peak condition.

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