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Nuclear Mechanics and Genome Regulation

2010-10-12 Science
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Release : 2010-10-12
Genre : Science
Kind : eBook
Book Rating : 108/5 ( reviews)

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Book Synopsis Nuclear Mechanics and Genome Regulation by :

Download or read book Nuclear Mechanics and Genome Regulation written by . This book was released on 2010-10-12. Available in PDF, EPUB and Kindle. Book excerpt: In recent years new discoveries have made this an exciting and important field of research. This exhaustive volume presents comprehensive chapters and detailed background information for researchers working with in the field of nuclear mechanics and genome regulation. - Both classic and state-of-the-art methods readily adaptable and designed to last the test of time - Relevant to clinicians and scientists working in a wide range of fields

Introduction to Nuclear Mechanics and Genome Regulation

2022-02-15 Medical
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Release : 2022-02-15
Genre : Medical
Kind : eBook
Book Rating : 454/5 ( reviews)

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Book Synopsis Introduction to Nuclear Mechanics and Genome Regulation by : G.V. Shivashankar

Download or read book Introduction to Nuclear Mechanics and Genome Regulation written by G.V. Shivashankar. This book was released on 2022-02-15. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Nuclear Mechanics and Genome Regulation provides a detailed discussion of the biophysical principles underlying nuclear organization and their role in determining tissue function, cell differentiation and homeostasis, and disease expression and management. Applied case studies and full cover images support concept illustration across a diverse range of chapters covering physico-chemical constraints in DNA, 3D organization of chromosomes and functional gene clusters, spatial dimensions of DNA transcription, replication, damage and repair, and more. With its practical approach and foundational focus, this book will be an invaluable reference for students, researchers and clinicians looking to understand this area of cutting-edge study. Contains applied case studies and full color images that support concept illustration Features a diverse range of chapters that cover the fundamentals of nuclear mechanics and genome regulation, including physico-chemical constraints in DNA Introduces advanced biophysical methods, bio-imaging methods, and new molecular biology tools for studying nuclear structures

Intermediate Filament Proteins

2016-01-19 Science
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Release : 2016-01-19
Genre : Science
Kind : eBook
Book Rating : 705/5 ( reviews)

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Book Synopsis Intermediate Filament Proteins by :

Download or read book Intermediate Filament Proteins written by . This book was released on 2016-01-19. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system.

Nuclear Structure and Gene Expression

1996-11-28 Science
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Release : 1996-11-28
Genre : Science
Kind : eBook
Book Rating : 812/5 ( reviews)

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Book Synopsis Nuclear Structure and Gene Expression by : R. Curtis Bird

Download or read book Nuclear Structure and Gene Expression written by R. Curtis Bird. This book was released on 1996-11-28. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Structure and Gene Expression assimilates the contributions of genome organization and of the components of the nuclear matrix to the control of DNA and RNA synthesis. Nuclear domains which accommodate DNA replication and gene expression are considered in relation to short-term developmental and homeostatic requirements as well as to long-term commitments to phenotypic gene expression in differentiated cells. Consideration is given to the involvement of nuclear structure in gene localization as well as to the targeting and concentration of transcription factors. Aberrations in nuclear architecture associated with and potentially functionally related to pathologies are evaluated. Tumor cells are described from the perspective of the striking modifications in both the composition and organization of nuclear components. Nuclear Structure and Gene Expression presents concepts as well as experimental approaches, which define functionality of nuclear morphology.* Mechanisms of interaction between nuclear structure and genes* Gene expression regulation by elements of the nuclear matrix* How nuclear structure exerts a regulatory effect on other aspects of cell function/physiology

A Coarse-Grained Molecular Dynamics Model of the Mammalian Nuclear Envelope

2021
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Release : 2021
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Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis A Coarse-Grained Molecular Dynamics Model of the Mammalian Nuclear Envelope by : Pranjal Singh

Download or read book A Coarse-Grained Molecular Dynamics Model of the Mammalian Nuclear Envelope written by Pranjal Singh. This book was released on 2021. Available in PDF, EPUB and Kindle. Book excerpt: The cell nucleus houses most of the genetic material in eukaryotic cells and is the site of many fundamental genome regulatory processes including cell division, gene expression, differentiation, and aging. The regulation of architecture of the nuclear envelope (NE) is essential for smooth operation of these processes. There is currently no physics-based model, theoretical or computational, which accounts for all significant interactions of subnuclear components in a common framework, leaving much of NE mechanics unexplored and poorly understood. We present a coarse-grained molecular dynamics model of the mammalian NE of unprecedented detail. A three-step protocol is shown to generate a coarse-grained nuclear envelope (CGNE) with experimentally consistent structure. The CGNE features a monolayer model of the nuclear membranes and a dynamically-linked meshwork model of the underlying nuclear lamina. Peripheral chromatin, which supports the meshwork from underneath and also interlaces with it, is modeled as a chain of mesoscale domains. The methodologies for in silico mechanical testing of the CGNE and extraction of metrics of NE viscoelasticity from the simulation data are described. Parameters are being tuned towards achieving experimental consistency of these viscoelastic properties. A revised CGNE model is planned to be published elsewhere in the near future.

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