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Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products

2023-04-25 Science
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Release : 2023-04-25
Genre : Science
Kind : eBook
Book Rating : 703/5 ( reviews)

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Book Synopsis Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products by : Sasadhar Majhi

Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi. This book was released on 2023-04-25. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.

Total Synthesis of Bioactive Natural Products

2019-04-27 Science
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Release : 2019-04-27
Genre : Science
Kind : eBook
Book Rating : 237/5 ( reviews)

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Book Synopsis Total Synthesis of Bioactive Natural Products by : Goutam Brahmachari

Download or read book Total Synthesis of Bioactive Natural Products written by Goutam Brahmachari. This book was released on 2019-04-27. Available in PDF, EPUB and Kindle. Book excerpt: Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule

Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

2011-11-23 Science
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Release : 2011-11-23
Genre : Science
Kind : eBook
Book Rating : 431/5 ( reviews)

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Book Synopsis Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by : Shinsuke Inuki

Download or read book Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds written by Shinsuke Inuki. This book was released on 2011-11-23. Available in PDF, EPUB and Kindle. Book excerpt: The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

Efficiency in Natural Product Total Synthesis

2018-07-20 Science
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Release : 2018-07-20
Genre : Science
Kind : eBook
Book Rating : 202/5 ( reviews)

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Book Synopsis Efficiency in Natural Product Total Synthesis by : Pei-Qiang Huang

Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang. This book was released on 2018-07-20. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Semisynthesis of Bioactive Compounds and their Biological Activities

2023-11-25 Science
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Release : 2023-11-25
Genre : Science
Kind : eBook
Book Rating : 705/5 ( reviews)

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Book Synopsis Semisynthesis of Bioactive Compounds and their Biological Activities by : Sasadhar Majhi

Download or read book Semisynthesis of Bioactive Compounds and their Biological Activities written by Sasadhar Majhi. This book was released on 2023-11-25. Available in PDF, EPUB and Kindle. Book excerpt: Semisynthesis of Bioactive Compounds and their Biological Activities explores the potential benefits of semisynthetic derivatives obtained from nature. Sections cover the natural distribution of parent compounds, semisynthesis and biological properties of semisynthetic derivatives, the applications of semisynthetic derivatives in diverse fields such as drug delivery, food production and medicine, an explanation of the current resistance mechanisms of antibiotics, clinical applications of semisynthetic analogues, the functions of plant alkaloids on human health, potential agricultural biotechnology in semisynthetic derivatives, and semisynthesis of natural products under greener conditions, this book provides a comprehensive resource on the topics presented. Sections include information about alternative sources of energy and superior greener technologies (microwave, sonochemistry), alternative reaction media (water, supercritical CO2, ionic liquids) and alternative eco-friendly catalysts (biocatalysts). This book will be an excellent resource for academicians, researchers and students focusing on synthesis as well as the biological community and industry professionals in drug development. - Focuses on the current resistance mechanisms of antibiotics, chemical derivatization of antibiotics, and clinical applications of semisynthetic derivatives. - Includes discussion of the semisynthesis of natural products using green tools, green solvents, and eco-friendly catalysts. - Illustrates the concept of toxicity, the merits of transition-metal-free reactions, and the semisynthesis of natural products by introducing the oxygen atom(s) under transition-metal-free conditions.

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