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Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds

2011-11-23 Science
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Release : 2011-11-23
Genre : Science
Kind : eBook
Book Rating : 431/5 ( reviews)

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Book Synopsis Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds by : Shinsuke Inuki

Download or read book Total Synthesis of Bioactive Natural Products by Palladium-Catalyzed Domino Cyclization of Allenes and Related Compounds written by Shinsuke Inuki. This book was released on 2011-11-23. Available in PDF, EPUB and Kindle. Book excerpt: The author has developed novel methodologies for highly efficient construction of functionalized heterocycles by palladium-catalyzed domino/cascade cyclization of allenes and related compounds containing appropriate nucleophilic group(s). Based on these methodologies, enantioselective total syntheses of bioactive natural products, pachastrissamine (26% overall yield in seven steps), lysergic acid (4.0% overall yield in fifteen steps), lysergol (3.6% overall yield in fifteen steps) and isolysergol (8.2% overall yield in eleven steps) have been achieved. These are more facile synthetic route than those previously reported. These findings would contribute to the development of efficient synthetic methods for biologically active compounds containing a complex structure.

The Total Synthesis of Natural Products, Volume 7

2009-09-22 Science
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Release : 2009-09-22
Genre : Science
Kind : eBook
Book Rating : 581/5 ( reviews)

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Book Synopsis The Total Synthesis of Natural Products, Volume 7 by : John ApSimon

Download or read book The Total Synthesis of Natural Products, Volume 7 written by John ApSimon. This book was released on 2009-09-22. Available in PDF, EPUB and Kindle. Book excerpt: The appearance of the seventh volume of The Total Synthesis of Natural Products signals the continued health of the art and science of organic synthesis. This new volume contains a chapter updating monoterpene synthesis and reviews the newer areas of leukotrienes and macro-cyclic lactones. The Total Synthesis of Natural Products, Volume Seven forms an integral part of the invaluable working reference begun in Volumes One through Six, to which chemists may turn for the available data on the total synthesis of complex molecules. Lessons learned from the synthetic challenges presented here by various natural products will serve as a sound base for this continually evolving field.

The Total Synthesis of Natural Products

2009-09-22 Science
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Release : 2009-09-22
Genre : Science
Kind : eBook
Book Rating : 59X/5 ( reviews)

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Book Synopsis The Total Synthesis of Natural Products by : John ApSimon

Download or read book The Total Synthesis of Natural Products written by John ApSimon. This book was released on 2009-09-22. Available in PDF, EPUB and Kindle. Book excerpt: Organic chemistry's innovative breadth is especially noteworthy in the area of natural products synthesis. Since the early 1970s, this landmark chemical reference has been documenting the newest and most important of these, in a readily understood format, that clearly traces each of their synthetic routes. Volume Eight, the latest in the series, contains a long-awaited look at the synthesis of tri- and tetracyclic diterpenes, along with the synthesis of naturally occurring quinones. Recent interest in the biologically important polysaccharides has led to a detailed consideration of that compound class. Finally, this new volume contains a look at the strategies and methods specific to natural products containing the spiroketal functional group. The Total Synthesis of Natural Products, Volume Eight, continues the meticulous work of the series, providing chemists with an entirely up-to-date and convenient guide to the critical new syntheses essential to organic chemistry's continuing evolution.

Efficiency in Natural Product Total Synthesis

2018-07-24 Science
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Release : 2018-07-24
Genre : Science
Kind : eBook
Book Rating : 210/5 ( reviews)

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Book Synopsis Efficiency in Natural Product Total Synthesis by : Pei-Qiang Huang

Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang. This book was released on 2018-07-24. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals

Natural Product Synthesis II

2005-02-11 Medical
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Release : 2005-02-11
Genre : Medical
Kind : eBook
Book Rating : 242/5 ( reviews)

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Book Synopsis Natural Product Synthesis II by : U. Beifuss

Download or read book Natural Product Synthesis II written by U. Beifuss. This book was released on 2005-02-11. Available in PDF, EPUB and Kindle. Book excerpt: T. Heckrodt and J. Mulzer: Marine Natural Products from Pseudopterogorgia Elisabethae: Structures, Biosynthesis, Pharmacology and Total Synthesis .-M. Kalesse: Recent Advances in Vinylogous Aldol Reactions and their Applications in Natural Product Synthesis .- U. Beifuss and M. Tietze: Methanophenazine and Other Biologically Active Phenazines .-H.-J. Knoelker: Occurrence, Biological Activity, and Convergent Organometallic Synthesis of Carbazole Alkaloids .-U. Nubbemeyer: Recent Advances in Charge Accelerated Aza-Claisen Rearrangements.- P. Metz: Synthetic Studies on the Pamamycin Macrodiolides

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