Immunity, Tumors and Aging: The Role of HSP70

2013-01-08 Medical

Author : Igor Malyshev
Release : 2013-01-08
Genre : Medical
Kind : eBook
Book Rating : 436/5 ( reviews)

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Book Synopsis Immunity, Tumors and Aging: The Role of HSP70 by : Igor Malyshev

Download or read book Immunity, Tumors and Aging: The Role of HSP70 written by Igor Malyshev. This book was released on 2013-01-08. Available in PDF, EPUB and Kindle. Book excerpt: The book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiac surgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.

Heat Shock Proteins in Cancer

2007-09-09 Medical

Author : Stuart K. Calderwood
Release : 2007-09-09
Genre : Medical
Kind : eBook
Book Rating : 012/5 ( reviews)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood. This book was released on 2007-09-09. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Heat Shock Proteins in the Immune System

2018-04-09 Medical

Author : Robert J. Binder
Release : 2018-04-09
Genre : Medical
Kind : eBook
Book Rating : 426/5 ( reviews)

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Book Synopsis Heat Shock Proteins in the Immune System by : Robert J. Binder

Download or read book Heat Shock Proteins in the Immune System written by Robert J. Binder. This book was released on 2018-04-09. Available in PDF, EPUB and Kindle. Book excerpt: Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Immune Surveillance

2012-12-02 Nature

Author : Richard T. Smith
Release : 2012-12-02
Genre : Nature
Kind : eBook
Book Rating : 260/5 ( reviews)

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Book Synopsis Immune Surveillance by : Richard T. Smith

Download or read book Immune Surveillance written by Richard T. Smith. This book was released on 2012-12-02. Available in PDF, EPUB and Kindle. Book excerpt: Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.

Hsp90 in Cancer: Beyond the Usual Suspects

2016-02-23 Medical

Author :
Release : 2016-02-23
Genre : Medical
Kind : eBook
Book Rating : 836/5 ( reviews)

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Book Synopsis Hsp90 in Cancer: Beyond the Usual Suspects by :

Download or read book Hsp90 in Cancer: Beyond the Usual Suspects written by . This book was released on 2016-02-23. Available in PDF, EPUB and Kindle. Book excerpt: Hsp90 in Cancer: Beyond the Usual Suspects, the latest volume in the Advances in Cancer Research series, focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins and discusses some of the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression. - Focuses on the multifunctional molecular chaperone Hsp90 which regulates the post-translational stability and function of a broad repertoire of client proteins - Highlights the rapidly evolving understanding of the fundamental roles of Hsp90 in cancer biology - Discusses the lesser-known aspects of how Hsp90 and its related family members enable oncogenic transformation and malignant progression

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Immunity, Tumors and Aging: The Role of HSP70

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