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Heat Shock Proteins: Potent Mediators of Inflammation and Immunity

2007-09-05 Medical
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Release : 2007-09-05
Genre : Medical
Kind : eBook
Book Rating : 854/5 ( reviews)

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Book Synopsis Heat Shock Proteins: Potent Mediators of Inflammation and Immunity by : Alexzander A.A. Asea

Download or read book Heat Shock Proteins: Potent Mediators of Inflammation and Immunity written by Alexzander A.A. Asea. This book was released on 2007-09-05. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Heat Shock Proteins in the Immune System

2018-04-09 Medical
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Release : 2018-04-09
Genre : Medical
Kind : eBook
Book Rating : 426/5 ( reviews)

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Book Synopsis Heat Shock Proteins in the Immune System by : Robert J. Binder

Download or read book Heat Shock Proteins in the Immune System written by Robert J. Binder. This book was released on 2018-04-09. Available in PDF, EPUB and Kindle. Book excerpt: Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

Heat Shock Proteins and Inflammation

2012-12-06 Medical
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Release : 2012-12-06
Genre : Medical
Kind : eBook
Book Rating : 286/5 ( reviews)

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Book Synopsis Heat Shock Proteins and Inflammation by : Willem van Eden

Download or read book Heat Shock Proteins and Inflammation written by Willem van Eden. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins (HSP) have received ample interest by immunologists over recent years. Initially they were found to be dominantly immunogenic microbial antigens. The connection with inflammation was established when it was uncovered that T cells specific for these antigens have a crucial role in the induction and regulation of experimental arthritis. Since then, the raised presence of immunity to HSPs in virtually all conditions of inflammation, including autoimmune diseases, transplant rejection and atherosclerosis, has emphasised the critical significance of immunity to HSPs in inflammatory diseases.

Heat Shock Proteins and Immune Response

1991 Health & Fitness
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Release : 1991
Genre : Health & Fitness
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Heat Shock Proteins and Immune Response by : Stefan H.E. Kaufmann

Download or read book Heat Shock Proteins and Immune Response written by Stefan H.E. Kaufmann. This book was released on 1991. Available in PDF, EPUB and Kindle. Book excerpt: Almost 30 years ago RITOSSA described a new puffing pattern in salivary gland chromosomes of Drosophila following heat shock. This was the first description of a heat shock response. For years, development in this field remained modest and it took another decade before the relevant gene products-the heat shock proteins (hsp's)-were made visible by TISSIERES and co-workers. Subsequently, progress advanced more rapidly and we can now state that studies on the heat shock response have contributed much to our understanding of various principles in molecular and cellular biology such as control of gene expression and regulation of protein translocation. More recently, the study of hsp's has converged with immunology. There are several reasons for this: The chaperone function of certain hsp's makes them particularly apt for central functions of immunity, including antigen presentation and immunoglobulin synthesis. Furthermore, an effective immune response is often caused or followed by stress situations as they arise during trauma, inflammation, transformation, infection, or autoimmune disease. Due to their abundance during stress, hsp's can provide prominent antigens in many of these situations. This volume contains 11 chapters written by well-known experts dealing with various facets of the fascinating liaison between hsp's and immunity. The particular relation of hsp's to the immune system may be best illustrated by their intimate association with the major histocompatibility gene complex. Still, as discussed by GONTHER, the relevance of this fact to our understanding of hsp functions in immunity remaif)s speculative.

Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease

2009-11-10 Medical
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Release : 2009-11-10
Genre : Medical
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Book Rating : 761/5 ( reviews)

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Book Synopsis Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease by : A. Graham Pockley

Download or read book Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease written by A. Graham Pockley. This book was released on 2009-11-10. Available in PDF, EPUB and Kindle. Book excerpt: Prokaryotic and Eukaryotic Heat Shock Proteins in Infectious Disease provides the most current review of the literature relating to the role and influence of heat shock (stress) proteins on the establishment, progression and resolution of infectious disease. Written by leaders in the field of heat shock proteins (HSP) and their biological and immunological properties, the contributors provide a fascinating insight into the complex relationship between, and the involvement of prokaryotic and eukaryotic HSP in disease states. It has been known for some considerable time that heat shock proteins from prokaryotic organisms are immunodominant molecules that are intimately involved in the induction of potential protective inflammatory responses, and this aspect of HSP biology is updated herein. In addition to regulating heat shock protein gene expression, the transcription factor HSF1 also appears to play an important role in regulating immune responses to infection. Heat shock proteins are now known to influence infectious disease processes in a number of diverse ways: they are involved in the propagation of prions, the replication and morphogenesis of viruses, and the resistance of parasites to chemotherapy. These proteins also appear to be important mediators of bacteria-host interactions and inflammation, the latter via interactions with cell surface molecules and structures such as Toll-like receptors and lipid rafts. Heat shock proteins can be expressed on the surface of infected cells, and this is likely to provide a target for the innate immune response. Elevated levels of circulating HSP are present in infectious diseases and these proteins might therefore regulate inflammatory responses to pathogenic challenge on a systemic basis. Heat shock proteins are also implicated in the impact of genital tract infections on the reproductive outcome, as well as in the local and systemic consequences of periodontal disease. Fever-range temperatures can induce the expression of heat shock proteins, and the final chapter in the book examines the influence of fever-range hyperthermia on a variety of cells and the organization of plasma membranes. This book is an essential read for graduates and postgraduates in Biology, pro- and eukaryotic Biochemistry, Immunology, Microbiology, Inflammatory and Infectious Disease, and Pathology.

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