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HSPs - Ambiguous Mediators of Immunity

2017-05-11
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Release : 2017-05-11
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Kind : eBook
Book Rating : 526/5 ( reviews)

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Book Synopsis HSPs - Ambiguous Mediators of Immunity by : Stuart Keith Calderwood

Download or read book HSPs - Ambiguous Mediators of Immunity written by Stuart Keith Calderwood. This book was released on 2017-05-11. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins (HSPs) were discovered as polypeptides induced by stress that can be found in all kingdoms of cellular organisms. Their functions were, a first enigmatic and these proteins were thus classified by molecular weight, as in—Hsp27, Hsp70, Hsp90, Hsp110. More recently, each of these size-classified molecules has attributed a role in protein folding, and they thus came to be known, as a class, as molecular chaperones. However, the they possess properties beyond chaperoning. Indeed, their discovery in the extracellular spaces suggested roles in regulation of the immune responses.

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity

2007-09-05 Medical
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Release : 2007-09-05
Genre : Medical
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Book Rating : 854/5 ( reviews)

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Book Synopsis Heat Shock Proteins: Potent Mediators of Inflammation and Immunity by : Alexzander A.A. Asea

Download or read book Heat Shock Proteins: Potent Mediators of Inflammation and Immunity written by Alexzander A.A. Asea. This book was released on 2007-09-05. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts’ immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step-wise fashion take the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provide answers as to its biological significance to the host.

Toll-Like Receptors (TLRs) and Innate Immunity

2007-12-11 Medical
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Release : 2007-12-11
Genre : Medical
Kind : eBook
Book Rating : 673/5 ( reviews)

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Book Synopsis Toll-Like Receptors (TLRs) and Innate Immunity by : Stefan Bauer

Download or read book Toll-Like Receptors (TLRs) and Innate Immunity written by Stefan Bauer. This book was released on 2007-12-11. Available in PDF, EPUB and Kindle. Book excerpt: Overall recent research on TLRs has led to tremendous increase in our understanding of early steps in pathogen recognition and will presumably lead to potent TLR targeting therapeutics in the future. This book reviews and highlights our recent understanding on the function and ligands of TLRs as well as their role in autoimmunity, dendritic cell activation and target structures for therapeutic intervention.

Tumor Microenvironment

2020-02-10 Medical
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Release : 2020-02-10
Genre : Medical
Kind : eBook
Book Rating : 840/5 ( reviews)

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Book Synopsis Tumor Microenvironment by : Alexander Birbrair

Download or read book Tumor Microenvironment written by Alexander Birbrair. This book was released on 2020-02-10. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment.Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Heat Shock Proteins in the Immune System

2018-04-09 Medical
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Release : 2018-04-09
Genre : Medical
Kind : eBook
Book Rating : 426/5 ( reviews)

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Book Synopsis Heat Shock Proteins in the Immune System by : Robert J. Binder

Download or read book Heat Shock Proteins in the Immune System written by Robert J. Binder. This book was released on 2018-04-09. Available in PDF, EPUB and Kindle. Book excerpt: Experts from around the world review the current field of the immunobiology of heat shock proteins, and provide a comprehensive account of how these molecules are spearheading efforts in the understanding of various pathways of the immune system. This one-stop resource contains numerous images to both help illustrate the research on heat shock proteins, and better clarify the field for the non-expert. Heat shock proteins (HSPs) were discovered in 1962 and were quickly recognized for their role in protecting cells from stress. Twenty years later, the immunogenicity of a select few HSPs was described, and for the past 30 years, these findings have been applied to numerous branches of immunology, including tumor immunology and immunosurveillance, immunotherapy, etiology of autoimmunity, immunotherapy of infectious diseases, and expression of innate receptors. While HSPs can be used to manipulate immune responses by exogenous administration, they appear to be involved in initiation of de novo immune responses to cancer and likely in the maintenance of immune homeostasis.

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