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Drosophila Models for Human Diseases

2018-06-27 Medical
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Release : 2018-06-27
Genre : Medical
Kind : eBook
Book Rating : 293/5 ( reviews)

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Book Synopsis Drosophila Models for Human Diseases by : Masamitsu Yamaguchi

Download or read book Drosophila Models for Human Diseases written by Masamitsu Yamaguchi. This book was released on 2018-06-27. Available in PDF, EPUB and Kindle. Book excerpt: Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.

Fly Models of Human Diseases

2017-01-02 Science
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Release : 2017-01-02
Genre : Science
Kind : eBook
Book Rating : 056/5 ( reviews)

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Book Synopsis Fly Models of Human Diseases by :

Download or read book Fly Models of Human Diseases written by . This book was released on 2017-01-02. Available in PDF, EPUB and Kindle. Book excerpt: Fly Models of Human Diseases provides users with a comprehensive survey on fly models of human diseases in the field of developmental biology. It is ideal for researchers in animal and plant development, and for students and professionals working in a variety of fields related to the topic. - Covers all aspects of fly models of human diseases - Includes contributions from an International board of authors - Provides a comprehensive set of reviews, covering such topics as cell proliferation, cell differentiation, and biological significance

Drosophila melanogaster

2018-02-28 Technology & Engineering
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Release : 2018-02-28
Genre : Technology & Engineering
Kind : eBook
Book Rating : 537/5 ( reviews)

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Book Synopsis Drosophila melanogaster by : Farzana Khan Perveen

Download or read book Drosophila melanogaster written by Farzana Khan Perveen. This book was released on 2018-02-28. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.

Scientific Frontiers in Developmental Toxicology and Risk Assessment

2000-12-21 Nature
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Release : 2000-12-21
Genre : Nature
Kind : eBook
Book Rating : 864/5 ( reviews)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council. This book was released on 2000-12-21. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Animal Models of Human Disease

2011-03-04 Science
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Release : 2011-03-04
Genre : Science
Kind : eBook
Book Rating : 792/5 ( reviews)

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Book Synopsis Animal Models of Human Disease by :

Download or read book Animal Models of Human Disease written by . This book was released on 2011-03-04. Available in PDF, EPUB and Kindle. Book excerpt: Animal experiments have contributed much to our understanding of mechanisms of disease and are important for determining new therapies. Animal Models of Human Disease reviews the latest research and developments in this field. - Discusses new discoveries, approaches, and ideas - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields

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