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Animal Models for the Study of Human Disease

2013-05-29 Science
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Release : 2013-05-29
Genre : Science
Kind : eBook
Book Rating : 125/5 ( reviews)

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Book Synopsis Animal Models for the Study of Human Disease by : P. Michael Conn

Download or read book Animal Models for the Study of Human Disease written by P. Michael Conn. This book was released on 2013-05-29. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse. - Organized by disease orientation for ease of searchability - Provides information on locating resources, animal alternatives and animal ethics - Covers a broad range of animal models used in research for human disease

Spontaneous Animal Models of Human Disease

1979 Medical
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Release : 1979
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Spontaneous Animal Models of Human Disease by : Edwin J. Andrews

Download or read book Spontaneous Animal Models of Human Disease written by Edwin J. Andrews. This book was released on 1979. Available in PDF, EPUB and Kindle. Book excerpt: This two-volume work gathers together the diverse information presently available on spontaneous animal models of human disease. In addition to providing a comprehensive review of existing models, the book presents many previous unpublished new models. The scope of this work is limited to spontaneous models. Neoplasia, infectious diseases including parasitism, and nutritionally induced or other types of experimental models have not been included. The sixteen parts of the book are alphabetically arranged according to organ system with over 230 authors contributing to the overall effort. In addition to many illustrations, the book features an extensive bibliography.

Cellular and Animal Models in Human Genomics Research

2019-07-30 Medical
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Release : 2019-07-30
Genre : Medical
Kind : eBook
Book Rating : 74X/5 ( reviews)

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Book Synopsis Cellular and Animal Models in Human Genomics Research by :

Download or read book Cellular and Animal Models in Human Genomics Research written by . This book was released on 2019-07-30. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. - Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies - Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health - Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Sourcebook of Models for Biomedical Research

2008 Medical
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Release : 2008
Genre : Medical
Kind : eBook
Book Rating : 333/5 ( reviews)

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Book Synopsis Sourcebook of Models for Biomedical Research by : P. Michael Conn

Download or read book Sourcebook of Models for Biomedical Research written by P. Michael Conn. This book was released on 2008. Available in PDF, EPUB and Kindle. Book excerpt: The collection of systems represented in Sourcebook of genomic programs, although this work is certainly well Models for Biomedical Research is an effort to re?ect the represented and indexed. diversity and utility of models that are used in biomedicine. Some models have been omitted due to page limitations That utility is based on the consideration that observations and we have encouraged the authors to use tables and made in particular organisms will provide insight into the ? gures to make comparisons of models so that observations workings of other, more complex, systems. Even the cell not available in primary publications can become useful to cycle in the simple yeast cell has similarities to that in the reader. humans and regulation with similar proteins occurs. We thank Richard Lansing and the staff at Humana for Some models have the advantage that the reproductive, guidance through the publication process. mitotic, development or aging cycles are rapid compared As this book was entering production, we learned of the with those in humans; others are utilized because individual loss of Tom Lanigan, Sr. Tom was a leader and innovator proteins may be studied in an advantageous way and that in scienti?c publishing and a good friend and colleague to have human homologs. Other organisms are facile to grow all in the exploratory enterprise. We dedicate this book to in laboratory settings or lend themselves to convenient analy- his memory. We will miss him greatly.

Improving the Utility and Translation of Animal Models for Nervous System Disorders

2013-04-25 Medical
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Release : 2013-04-25
Genre : Medical
Kind : eBook
Book Rating : 335/5 ( reviews)

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Book Synopsis Improving the Utility and Translation of Animal Models for Nervous System Disorders by : Institute of Medicine

Download or read book Improving the Utility and Translation of Animal Models for Nervous System Disorders written by Institute of Medicine. This book was released on 2013-04-25. Available in PDF, EPUB and Kindle. Book excerpt: Nervous system diseases and disorders are highly prevalent and substantially contribute to the overall disease burden. Despite significant information provided by the use of animal models in the understanding of the biology of nervous system disorders and the development of therapeutics; limitations have also been identified. Treatment options that are high in efficacy and low in side effects are still lacking for many diseases and, in some cases are nonexistent. A particular problem in drug development is the high rate of attrition in Phase II and III clinical trials. Why do many therapeutics show promise in preclinical animal models but then fail to elicit predicted effects when tested in humans? On March 28 and 29, 2012, the Institute of Medicine Forum on Neuroscience and Nervous System Disorders convened the workshop "Improving Translation of Animal Models for Nervous System Disorders" to discuss potential opportunities for maximizing the translation of new therapies from animal models to clinical practice. The primary focus of the workshop was to examine mechanisms for increasing the efficiency of translational neuroscience research through discussions about how and when to use animal models most effectively and then best approaches for the interpretation of the data collected. Specifically, the workshop objectives were to: discuss key issues that contribute to poor translation of animal models in nervous system disorders, examine case studies that highlight successes and failures in the development and application of animal models, consider strategies to increase the scientific rigor of preclinical efficacy testing, explore the benefits and challenges to developing standardized animal and behavioral models. Improving the Utility and Translation of Animal Models for Nervous System Disorders: Workshop Summary also identifies methods to facilitate development of corresponding animal and clinical endpoints, indentifies methods that would maximize bidirectional translation between basic and clinical research and determines the next steps that will be critical for improvement of the development and testing of animal models of disorders of the nervous system.

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