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Cell Aging: Molecular Mechanisms and Implications for Disease

2013-12-18 Science
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Release : 2013-12-18
Genre : Science
Kind : eBook
Book Rating : 799/5 ( reviews)

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Book Synopsis Cell Aging: Molecular Mechanisms and Implications for Disease by : Christian Behl

Download or read book Cell Aging: Molecular Mechanisms and Implications for Disease written by Christian Behl. This book was released on 2013-12-18. Available in PDF, EPUB and Kindle. Book excerpt: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Aging and Age-Related Disorders From Molecular Mechanisms to Therapies

2019-08-19 Science
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Release : 2019-08-19
Genre : Science
Kind : eBook
Book Rating : 555/5 ( reviews)

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Book Synopsis Aging and Age-Related Disorders From Molecular Mechanisms to Therapies by : Vladimir Titorenko

Download or read book Aging and Age-Related Disorders From Molecular Mechanisms to Therapies written by Vladimir Titorenko. This book was released on 2019-08-19. Available in PDF, EPUB and Kindle. Book excerpt: Aging of unicellular and multicellular eukaryotic organisms is a convoluted biological phenomenon, which is manifested as an age-related functional decline caused by progressive dysregulation of certain cellular and organismal processes. Many chronic diseases are associated with human aging. These aging-associated diseases include cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, diabetes, osteoarthritis, osteoporosis, sarcopenia, stroke, neurodegenerative diseases (including Parkinson’s, Alzheimer’s, and Huntington’s diseases), and many forms of cancer. Studies in yeast, roundworms, fruit flies, fishes, mice, primates, and humans have provided evidence that the major aspects and basic mechanisms of aging and aging-associated pathology are conserved across phyla. The focus of this International Journal of Molecular Sciences Special Issue is on molecular and cellular mechanisms, diagnostics, and therapies and diseases of aging. Fifteen original research and review articles in this Special Issue provide important insights into how various genetic, dietary, and pharmacological interventions can affect certain longevity-defining cellular and organismal processes to delay aging and postpone the onset of age-related pathologies in evolutionarily diverse organisms. These articles outline the most important unanswered questions and directions for future research in the vibrant and rapidly evolving fields of mechanisms of biological aging, aging-associated diseases, and aging-delaying therapies.

Molecular Mechanisms of Adult Stem Cell Aging

2010 Science
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Release : 2010
Genre : Science
Kind : eBook
Book Rating : 434/5 ( reviews)

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Book Synopsis Molecular Mechanisms of Adult Stem Cell Aging by : K. Lenhard Rudolph

Download or read book Molecular Mechanisms of Adult Stem Cell Aging written by K. Lenhard Rudolph. This book was released on 2010. Available in PDF, EPUB and Kindle. Book excerpt: "There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis. Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology."--Publisher's description.

Molecular Mechanisms of the Aging Process and Rejuvenation

2016-08-31 Medical
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Release : 2016-08-31
Genre : Medical
Kind : eBook
Book Rating : 680/5 ( reviews)

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Book Synopsis Molecular Mechanisms of the Aging Process and Rejuvenation by : Naofumi Shiomi

Download or read book Molecular Mechanisms of the Aging Process and Rejuvenation written by Naofumi Shiomi. This book was released on 2016-08-31. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.

Molecular Mechanisms of Aging

2012-12-06 Medical
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Release : 2012-12-06
Genre : Medical
Kind : eBook
Book Rating : 240/5 ( reviews)

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Book Synopsis Molecular Mechanisms of Aging by : Konrad Beyreuther

Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt:

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