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Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

2020-11-17 Science
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Release : 2020-11-17
Genre : Science
Kind : eBook
Book Rating : 116/5 ( reviews)

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Book Synopsis Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance by : Andrew Freywald

Download or read book Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance written by Andrew Freywald. This book was released on 2020-11-17. Available in PDF, EPUB and Kindle. Book excerpt: Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Cancer Drug Resistance

2007-11-09 Medical
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Release : 2007-11-09
Genre : Medical
Kind : eBook
Book Rating : 359/5 ( reviews)

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Book Synopsis Cancer Drug Resistance by : Beverly A. Teicher

Download or read book Cancer Drug Resistance written by Beverly A. Teicher. This book was released on 2007-11-09. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy

2013-07-04 Medical
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Release : 2013-07-04
Genre : Medical
Kind : eBook
Book Rating : 706/5 ( reviews)

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Book Synopsis Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy by : Benjamin Bonavida

Download or read book Molecular Mechanisms of Tumor Cell Resistance to Chemotherapy written by Benjamin Bonavida. This book was released on 2013-07-04. Available in PDF, EPUB and Kindle. Book excerpt: ​​​​​This volume gives the latest developments in on the mechanisms of cancer cell resistance to apoptotic stimuli, which eventually result in cancer progression and metastasis. One of the main challenges in cancer research is to develop new therapies to combat resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance to cytotoxic drug-induced apoptosis. These mechanisms should reveal gene products that directly regulate resistance in order to develop new drugs that target these resistance factors and such new drugs may either be selective or common to various cancers. If successful, new drugs may not be toxic and may be used effectively in combination with subtoxic conventional drugs to achieve synergy and to reverse tumor cell resistance. The research developments presented in this book can be translated to produce better clinical responses to resistant tumors.

Drug Resistance in Cancer

2009-06-11 Medical
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Release : 2009-06-11
Genre : Medical
Kind : eBook
Book Rating : 706/5 ( reviews)

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Book Synopsis Drug Resistance in Cancer by : James H. Goldie

Download or read book Drug Resistance in Cancer written by James H. Goldie. This book was released on 2009-06-11. Available in PDF, EPUB and Kindle. Book excerpt: Drug resistance in cancer, whereby a portion of cancer cells evades chemotherapy, poses a profound and continuing challenge for the effective treatment of cancer. The principles underlying the biological mechanisms behind this phenomenon are clearly explained in this volume. A deeper understanding of drug resistance requires a quantitative appreciation of the dynamic forces that shape tumor growth, including spontaneous mutation and selection processes. The authors seek to explain and to simplify these complex mechanisms, and to place them in a clinical context. Clearly explained mathematical models are used to illustrate the biological principles and provide an insight into tumor development and the effectiveness and limitations of drug treatment. The volume is suitable for those with a nonmathematical background and aims to enhance the effectiveness of cancer therapy. This is the first book to provide such an integrated account, in a form accessible to both doctor and scientist.

Drug Resistance in Breast Cancer – Mechanisms and Approaches to Overcome Chemoresistance

2023-02-03 Medical
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Release : 2023-02-03
Genre : Medical
Kind : eBook
Book Rating : 654/5 ( reviews)

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Book Synopsis Drug Resistance in Breast Cancer – Mechanisms and Approaches to Overcome Chemoresistance by : Maria Rosaria De Miglio

Download or read book Drug Resistance in Breast Cancer – Mechanisms and Approaches to Overcome Chemoresistance written by Maria Rosaria De Miglio. This book was released on 2023-02-03. Available in PDF, EPUB and Kindle. Book excerpt:

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