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Adult Stem Cells in Aging, Diseases and Cancer

2014-12-22 Medical
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Release : 2014-12-22
Genre : Medical
Kind : eBook
Book Rating : 324/5 ( reviews)

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Book Synopsis Adult Stem Cells in Aging, Diseases and Cancer by : K.L. Rudolph

Download or read book Adult Stem Cells in Aging, Diseases and Cancer written by K.L. Rudolph. This book was released on 2014-12-22. Available in PDF, EPUB and Kindle. Book excerpt: The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Telomeres and Telomerase in Aging, Disease, and Cancer

2007-11-07 Medical
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Release : 2007-11-07
Genre : Medical
Kind : eBook
Book Rating : 09X/5 ( reviews)

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Book Synopsis Telomeres and Telomerase in Aging, Disease, and Cancer by : K. Lenhard Rudolph

Download or read book Telomeres and Telomerase in Aging, Disease, and Cancer written by K. Lenhard Rudolph. This book was released on 2007-11-07. Available in PDF, EPUB and Kindle. Book excerpt: Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Molecular Mechanisms of Adult Stem Cell Aging

2010 Science
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Release : 2010
Genre : Science
Kind : eBook
Book Rating : 434/5 ( reviews)

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Book Synopsis Molecular Mechanisms of Adult Stem Cell Aging by : K. Lenhard Rudolph

Download or read book Molecular Mechanisms of Adult Stem Cell Aging written by K. Lenhard Rudolph. This book was released on 2010. Available in PDF, EPUB and Kindle. Book excerpt: "There is growing evidence that adult stem cells age. This process can result in alterations in the number and function of stem cells, leading to distinct phenotypic outcomes in different organ systems. This publication provides an outstanding overview of this emerging field. The molecular causes of stem cell aging remain to be defined. Stem cell aging can involve cell-intrinsic as well as cell-extrinsic alterations affecting the stem cell niche or the macroenvironment. Stem cells have a longer life span than other cell populations and retain a capacity to proliferate and differentiate in adult organs. The aging of adult stem cells plays a key role in the decline of organ maintenance and regenerative potential during aging and during the end stage of chronic diseases. In addition, it can contribute to stem cell transformation and carcinogenesis. Molecular Mechanisms of Adult Stem Cell Aging will appeal to scientists working in the fields such as stem cells, aging, regeneration and cancer. This subject matter should be of interest to physicians and scientists specializing in geriatric medicine, internal medicine, and surgery. It is also likely to be an invaluable resource for medical students and biologists who wish to enhance their understanding of molecular and stem cell biology."--Publisher's description.

Exosomes, Stem Cells and MicroRNA

2018-05-12 Science
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Release : 2018-05-12
Genre : Science
Kind : eBook
Book Rating : 704/5 ( reviews)

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Book Synopsis Exosomes, Stem Cells and MicroRNA by : Karl L. Mettinger

Download or read book Exosomes, Stem Cells and MicroRNA written by Karl L. Mettinger. This book was released on 2018-05-12. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

Stem Cells and Aging

2021-03-17 Science
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Release : 2021-03-17
Genre : Science
Kind : eBook
Book Rating : 133/5 ( reviews)

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Book Synopsis Stem Cells and Aging by : Surajit Pathak

Download or read book Stem Cells and Aging written by Surajit Pathak. This book was released on 2021-03-17. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

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