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Wnt Signaling in Embryonic Development

2007-01-18 Science
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Release : 2007-01-18
Genre : Science
Kind : eBook
Book Rating : 742/5 ( reviews)

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Book Synopsis Wnt Signaling in Embryonic Development by : Sergei Sokol

Download or read book Wnt Signaling in Embryonic Development written by Sergei Sokol. This book was released on 2007-01-18. Available in PDF, EPUB and Kindle. Book excerpt: A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes. * Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton * Offers insight to large genomic data that are now available for the analysis of Wnt gene targets * Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity

Wnt Signaling in Embryonic Development

2011-09-22 Science
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Release : 2011-09-22
Genre : Science
Kind : eBook
Book Rating : 34X/5 ( reviews)

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Book Synopsis Wnt Signaling in Embryonic Development by : Sergei Y. Sokol

Download or read book Wnt Signaling in Embryonic Development written by Sergei Y. Sokol. This book was released on 2011-09-22. Available in PDF, EPUB and Kindle. Book excerpt: A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes. * Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton* Offers insight to large genomic data that are now available for the analysis of Wnt gene targets* Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity

Signalling Pathways in Embryonic Development

2017-11-30
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Release : 2017-11-30
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Kind : eBook
Book Rating : 464/5 ( reviews)

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Book Synopsis Signalling Pathways in Embryonic Development by : Juan J. Sanz-Ezquerro

Download or read book Signalling Pathways in Embryonic Development written by Juan J. Sanz-Ezquerro. This book was released on 2017-11-30. Available in PDF, EPUB and Kindle. Book excerpt: The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.

Wnt Signaling in Development and Disease

2014-05-12 Science
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Release : 2014-05-12
Genre : Science
Kind : eBook
Book Rating : 167/5 ( reviews)

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Book Synopsis Wnt Signaling in Development and Disease by : Stefan P. Hoppler

Download or read book Wnt Signaling in Development and Disease written by Stefan P. Hoppler. This book was released on 2014-05-12. Available in PDF, EPUB and Kindle. Book excerpt: Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.

Cell Signaling During Mammalian Early Embryo Development

2015-05-08 Science
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Release : 2015-05-08
Genre : Science
Kind : eBook
Book Rating : 80X/5 ( reviews)

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Book Synopsis Cell Signaling During Mammalian Early Embryo Development by : Henry J. Leese

Download or read book Cell Signaling During Mammalian Early Embryo Development written by Henry J. Leese. This book was released on 2015-05-08. Available in PDF, EPUB and Kindle. Book excerpt: The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

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