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Vascular Growth Factors and Angiogenesis

2012-12-06 Medical
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Release : 2012-12-06
Genre : Medical
Kind : eBook
Book Rating : 532/5 ( reviews)

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Book Synopsis Vascular Growth Factors and Angiogenesis by : Lena Claesson-Welsh

Download or read book Vascular Growth Factors and Angiogenesis written by Lena Claesson-Welsh. This book was released on 2012-12-06. Available in PDF, EPUB and Kindle. Book excerpt: Currently, the cellular and molecular mechanisms governing the development and regulation of the vasculature are studied in tensely and the field is rapidly progressing. Recently, novel growth factors and growth factor receptors specifically acting on endothelial cells have been discovered. Through these factors, communication networks are established between endothelial cells, the basement membrane and the pericytes; this interplay is critical for the regulated development and maintenance of the vasculature. The awareness that deregulated angiogenesis con tributes to the progression of a number of diseases, such as cancer and inflammatory diseases, has clearly spurred the field to move forward. The focus of this book is on two important classes of endothelial cell specific growth factors, the vascular endothelial growth factor (VEGF) family, and the angiopoietins, and on their mechanisms of action. The reader will find up-to-date, fo cused reviews, which give the current picture, and indicate future directions. I would like to honor Dr. Judah Folkman for his important contributions to the establishment of the field and thank him for his support. Lena Claesson-Welsh List of Contents N. FERRARA Vascular Endothelial Growth Factor: Molecular and Biological Aspects . . . . . . . . . . . . . . . . . . . . . . . . . . M. G. PERSICO, V. VINCENTI and T. DIPALMA Structure, Expression and Receptor-Binding Properties of Placenta Growth Factor (PIGF) . . . . . . . . . . . . . . . . . 31 U. ERIKSSON and K. ALiTALO Structure, Expression and Receptor-Binding Properties of Novel Vascular Endothelial Growth Factors. . . . . . . . . 41 M. SHIBUYA, N. ITo and L. CLAESSON-WELSH Structure and Function of Vascular Endothelial Growth Factor Receptor-I and -2 . . . . . . . . . . . . . . . . . . 59 J. TAIPALE, T. MAKINEN, E. ARIGHI, E.

Vascular Growth Factors and Angiogenesis

1998-11-19
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Release : 1998-11-19
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Kind : eBook
Book Rating : 545/5 ( reviews)

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Book Synopsis Vascular Growth Factors and Angiogenesis by : Lena Claesson-Welsh

Download or read book Vascular Growth Factors and Angiogenesis written by Lena Claesson-Welsh. This book was released on 1998-11-19. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on a family of growth factors and their receptors, known as vascular endothelial growth factors (VEGF's). VEGF's are critical for endothelial cell function, both during physiological and pathological conditions. Thus, tumors depend on VEGF in order to promote ingrowth of blood vessels. Without VEGF, blood vessels will not form. There is growing awareness that deregulated production or action of VEGF is initiating or driving a large number of diseases. The book is written by the leading scientists in the field for an audience with medical or life science background, and presents an overview of the current knowledge in the area of VEGF and VEDG receptor structure and function in a series of reviews spanning from molecular signal transduction and cellular biology to the clinic.

Vascular Development

2007-08-20 Science
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Release : 2007-08-20
Genre : Science
Kind : eBook
Book Rating : 429/5 ( reviews)

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Book Synopsis Vascular Development by : Derek J. Chadwick

Download or read book Vascular Development written by Derek J. Chadwick. This book was released on 2007-08-20. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.

Regulation of Angiogenesis

2013-03-12 Science
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Release : 2013-03-12
Genre : Science
Kind : eBook
Book Rating : 060/5 ( reviews)

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Book Synopsis Regulation of Angiogenesis by : I.D. Goldberg

Download or read book Regulation of Angiogenesis written by I.D. Goldberg. This book was released on 2013-03-12. Available in PDF, EPUB and Kindle. Book excerpt: We now know that excessive angiogenesis contributes to the development of a variety of disease processes, including cancer, chronic inflammatory disease, and diabetic retinopathy. On the other hand, insufficient angiogenesis may impair wound healing and organ repair. This volume describes recent advances in understanding the molecular regulation of angiogenesis. Subjects covered include important pro-angiogenic growth factors (e.g., vascular endothelial growth factor/vascular permeability factor, scatter factor/hepatocyte growth factor) and their receptors; angiogenesis inhibitors (e.g., thrombospondin-1, angiostatin); extracellular matrix factors (e.g., laminin) and specific vascular integrins (avb3 and avb5) that regulate angiogenesis; the roles of fibrin and the fibrinolytic system in angiogenesis; physical factors that regulate angiogenesis (hypoxia, pH); mechanisms by which specific cell types (macrophages, pericytes) regulate angiogenesis; and lymphangiogenesis, a subject often ignored in volumes of this type. Several chapters are also devoted to the prognostic and therapeutic implications of tumor angiogenesis, a subject of great interest to clinicians. Reflecting the latest advances in this exciting and expanding field, this comprehensive and authoritative monograph will prove invaluable to cell biologists, cancer researchers and pharmacologists.

Vascular Biology of the Placenta

2017-06-23 Medical
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Release : 2017-06-23
Genre : Medical
Kind : eBook
Book Rating : 514/5 ( reviews)

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Book Synopsis Vascular Biology of the Placenta by : Yuping Wang

Download or read book Vascular Biology of the Placenta written by Yuping Wang. This book was released on 2017-06-23. Available in PDF, EPUB and Kindle. Book excerpt: The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.

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