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Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies

2022-11-30 Medical
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Release : 2022-11-30
Genre : Medical
Kind : eBook
Book Rating : 426/5 ( reviews)

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Book Synopsis Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies by : Ludovica Monti

Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies written by Ludovica Monti. This book was released on 2022-11-30. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

2009-01-14 Medical
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Release : 2009-01-14
Genre : Medical
Kind : eBook
Book Rating : 366/5 ( reviews)

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Book Synopsis The Role of Microtubules in Cell Biology, Neurobiology, and Oncology by : Antonio Tito Fojo

Download or read book The Role of Microtubules in Cell Biology, Neurobiology, and Oncology written by Antonio Tito Fojo. This book was released on 2009-01-14. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

2008-06-11 Medical
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Release : 2008-06-11
Genre : Medical
Kind : eBook
Book Rating : 940/5 ( reviews)

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Book Synopsis The Role of Microtubules in Cell Biology, Neurobiology, and Oncology by : Antonio Tito Fojo

Download or read book The Role of Microtubules in Cell Biology, Neurobiology, and Oncology written by Antonio Tito Fojo. This book was released on 2008-06-11. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting

2022-11-30 Medical
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Release : 2022-11-30
Genre : Medical
Kind : eBook
Book Rating : 442/5 ( reviews)

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Book Synopsis Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting by : Eleonora Cella

Download or read book Multi-drug resistant Klebsiella pneumoniae strains circulating in hospital setting written by Eleonora Cella. This book was released on 2022-11-30. Available in PDF, EPUB and Kindle. Book excerpt: Carbapenems resistant Enterobacteriaceae infections are increasing worldwide representing an emerging public health problem. The application of phylogenetic and phylodynamic analyses to bacterial whole genome sequencing (WGS) data have become essential in epidemiological surveillance of MDR pathogens to discern outbreak from non-outbreak strains in both community and hospital settings. In this study, K. pneumoniae strains circulating within different wards of university hospital were collected and WGS applied. Moreover a microbiological surveillance on duedonoscopes was performed to evaluate their reprocessing. The aim was to infer the origin and the spread of K. pneumoniae nosocomial strains and to clarify the epidemiological transmission as so as the eventual reservoir in the hospital setting supporting the epidemiological surveillance and infections control strategies. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines

2022-11-30 Medical
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Release : 2022-11-30
Genre : Medical
Kind : eBook
Book Rating : 450/5 ( reviews)

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Book Synopsis Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines by : Maria Ferraiuolo

Download or read book Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines written by Maria Ferraiuolo. This book was released on 2022-11-30. Available in PDF, EPUB and Kindle. Book excerpt: Osteosarcoma (OS) is the most aggressive type of primary solid tumor that develops in bone. Whilst conventional chemotherapy can improve survival rates, the outcome for patients with metastatic or recurrent OS remains poor, so novel treatment agents and strategies are required. Previously published works indicate that Agave exhibits anticancer properties. In the present study, anticancer effects of Agave leaf extract were investigated in the OS cells, discovering that Agave inhibits cell growth and cell migration, and sensitizes OS cells to cisplatin (CDDP), to overcome chemoresistance. Agave’s mechanisms of action include an initial process in which Agave induces YAP/TAZ oncogenic protein degradation, followed by a secondary event whereby Agave inhibits YAP/TAZ transcription through NF-κB p65:p50 heterodimers deregulation. Winner of the Competition “Prize for PhD Thesis 2020” arranged by Sapienza University Press.

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