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Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle

2024
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Release : 2024
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Book Synopsis Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle by : Yunxiao Zhang

Download or read book Towards Personalized Cardiac Modeling of Failing Heart with Engineered Heart Muscle written by Yunxiao Zhang. This book was released on 2024. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation investigates the biomechanics of the left ventricle across multiple geometric levels toward personalized cardiac modeling with engineered heart muscle. Firstly, a physics-based model for the EDPVR and ESPVR of the LV represented by a thick-wall sphere with interpretable parameters is proposed, and the PV relationships of the LV are investigated. Then, the influence of fiber architecture on LV pump function is investigated using an idealized LV model of a truncated ellipsoid. Finally, a workflow for personalized cardiac modeling is developed, which benefits public health by...

Mechanobiology in Health and Disease

2018-08-09 Medical
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Release : 2018-08-09
Genre : Medical
Kind : eBook
Book Rating : 530/5 ( reviews)

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Book Synopsis Mechanobiology in Health and Disease by : Stefaan Verbruggen

Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen. This book was released on 2018-08-09. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science

Patient-Specific Modeling of the Cardiovascular System

2014-10-19 Science
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Release : 2014-10-19
Genre : Science
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Book Rating : 421/5 ( reviews)

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Book Synopsis Patient-Specific Modeling of the Cardiovascular System by : Roy C.P. Kerckhoffs

Download or read book Patient-Specific Modeling of the Cardiovascular System written by Roy C.P. Kerckhoffs. This book was released on 2014-10-19. Available in PDF, EPUB and Kindle. Book excerpt: Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Cardiac Tissue Engineering

2014-07-29 Science
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Release : 2014-07-29
Genre : Science
Kind : eBook
Book Rating : 465/5 ( reviews)

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Book Synopsis Cardiac Tissue Engineering by : Milica Radisic

Download or read book Cardiac Tissue Engineering written by Milica Radisic. This book was released on 2014-07-29. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI

2019-02-15
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Release : 2019-02-15
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Book Rating : 172/5 ( reviews)

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Book Synopsis Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI by : Belén Casas Garcia

Download or read book Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI written by Belén Casas Garcia. This book was released on 2019-02-15. Available in PDF, EPUB and Kindle. Book excerpt: Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.

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