Author : Thomas F. O'Connor
Release : 2007
Genre :
Kind : eBook
Book Rating : 697/5 ( reviews)
Book Synopsis The Rational Design of Protein Solutions by : Thomas F. O'Connor
Download or read book The Rational Design of Protein Solutions written by Thomas F. O'Connor. This book was released on 2007. Available in PDF, EPUB and Kindle. Book excerpt: The effects of cosolutes on protein stability were further studied using simulations of a simple "HP" protein in the presence of solute molecules that are devoid of enthalpic interactions. It was found that entropic interactions were able to account for the increase in stability of our model protein as well as the exclusion of solute molecules from the protein surface. This simulation study also examined the impact of cosolute size and shape on its ability to stabilize the native state of the model protein.