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The Extracellular Environment's Effect on Cellular Processes: An In Vitro Study of Mechanical and Chemical Cues on Human Mesenchymal Stem Cells and C17.2 Neural Stem Cells

2013
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Release : 2013
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Kind : eBook
Book Rating : 284/5 ( reviews)

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Book Synopsis The Extracellular Environment's Effect on Cellular Processes: An In Vitro Study of Mechanical and Chemical Cues on Human Mesenchymal Stem Cells and C17.2 Neural Stem Cells by : Meghan E. Casey

Download or read book The Extracellular Environment's Effect on Cellular Processes: An In Vitro Study of Mechanical and Chemical Cues on Human Mesenchymal Stem Cells and C17.2 Neural Stem Cells written by Meghan E. Casey. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Stem cells are widely used in the area of tissue engineering. The ability of cells to interact with materials on the nano- and micro- level is important in the success of the biomaterial. It is well-known that cells respond to their micro- and nano-environments through a process termed chemo-mechanotransduction.

The Effect of Mechanical Cues on in Vitro Aging and Differentiation of Human Mesenchymal Stem Cells

2013
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Release : 2013
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Kind : eBook
Book Rating : 038/5 ( reviews)

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Book Synopsis The Effect of Mechanical Cues on in Vitro Aging and Differentiation of Human Mesenchymal Stem Cells by : Courtney Eileen LeBlon

Download or read book The Effect of Mechanical Cues on in Vitro Aging and Differentiation of Human Mesenchymal Stem Cells written by Courtney Eileen LeBlon. This book was released on 2013. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering is a field that aims to replace or repair damaged tissue through the use of stem cells, biomaterials, and biomolecules. Human mesenchymal stem cells are multipotent adult stem cells that can be autologously transplanted. This work describes the effect of mechanical cues on human mesenchymal stem cells. An analysis on the age-related stiffening of these cells, and its effect on osteogenic and myogenic differentiation, is presented. This study gives insight to those using stem cells in vitro for extended periods of time. The effect of mechanical loading on stem cell differentiation is examined. Tensile and compressive loading are used to induce myogenic and osteogenic differentiation, respectively, in the absence of chemical cues. This study demonstrates that loading alone can accelerate differentiation. A 3-D cell culture method for cardiomyocyte differentiation is also explored. Numerous cardiomyocyte markers were observed, signifying that this method may be superior to chemical induction methods. A biodegradation study of four porous polymers is also presented, as scaffold choice is of great importance in the area of tissue engineering. This research provides guidance to those using human mesenchymal stem cells for tissue engineering.

The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differntiation and Extracellular Matrix Production by Mesenchymal Stem Cells

2011 Biomechanics
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Release : 2011
Genre : Biomechanics
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Book Synopsis The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differntiation and Extracellular Matrix Production by Mesenchymal Stem Cells by : Derek M. Doroski

Download or read book The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differntiation and Extracellular Matrix Production by Mesenchymal Stem Cells written by Derek M. Doroski. This book was released on 2011. Available in PDF, EPUB and Kindle. Book excerpt: Ligament/tendon tissue engineering has the potential to provide therapies that overcome the limitations of incomplete natural healing responses and inadequate graft materials. While ligament/tendon fibroblasts are an obvious choice of cell type for these applications, difficulties associated with finding a suitable cell source have limited their utility. Mesenchymal stem cells/marrow stromal cells (MSCs) are seen as a viable alternative since they can be harvested through routine medical procedures and can be differentiated toward a ligament/tendon fibroblast lineage. Further study is needed to create an optimal biomaterial/biomechanical environment for ligament/tendon fibroblastic differentiation of MSCs. The overall goal of this dissertation was to improve the understanding of the role that biomechanical stimulation and the biomaterial environment play, both independently and combined, on human MSC (hMSC) differentiation toward a ligament/tendon fibroblast phenotype. Specifically, the effects of cyclic tensile stimuli were studied in a biomaterial environment that provided controlled presentation of biological moieties. The influence of an enzymatically-degradable biomaterial environment on hMSC differentiation was investigated by creating biomaterials containing enzymatically-cleavable moieties. The role that preculture may play in tensile responses of hMSCs was also explored. Together, these studies provided insights into the contributions of the biomaterial and biomechanical environment to hMSC differentiation toward a ligament/tendon fibroblast phenotype.

The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differentiation and Extracellular Matrix Production by Mesenchymal Stem Cells

2011
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Release : 2011
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Book Synopsis The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differentiation and Extracellular Matrix Production by Mesenchymal Stem Cells by : Derek Doroski

Download or read book The Effects of Tensile Loading and Extracellular Environmental Cues on Fibroblastic Differentiation and Extracellular Matrix Production by Mesenchymal Stem Cells written by Derek Doroski. This book was released on 2011. Available in PDF, EPUB and Kindle. Book excerpt:

Mesenchymal Stem Cells in Human Health and Diseases

2020-01-07 Science
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Release : 2020-01-07
Genre : Science
Kind : eBook
Book Rating : 334/5 ( reviews)

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Book Synopsis Mesenchymal Stem Cells in Human Health and Diseases by : Ahmed El-Hashash

Download or read book Mesenchymal Stem Cells in Human Health and Diseases written by Ahmed El-Hashash. This book was released on 2020-01-07. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal Stem Cells in Human Health and Diseases provides a contemporary overview of the fast-moving field of MSC biology, regenerative medicine and therapeutics. MSCs offer the potential to dramatically reduce human suffering from disease. Numerous MSC-based studies are ongoing each year, each offering hope for novel treatments in human disease. This book provides information on MSC application in well-studied human diseases and tissue repair/regeneration and recent advances in their research and treatment. These discoveries are placed within the structural context of tissue and developmental biology in sections dealing with recent advances in our understanding of MSC biology. Includes insights ranging from MSC biology and development through the derivation and identification and properties of MSCs Helps to identify potential innovative solutions for restoring normal morphogenesis and/or regeneration of diseased organs Discusses the fact-based promise of MSC therapeutics and regenerative medicine in the real world

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