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The Drug Hunters

2016-12-13 Science
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Release : 2016-12-13
Genre : Science
Kind : eBook
Book Rating : 195/5 ( reviews)

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Book Synopsis The Drug Hunters by : Donald R. Kirsch

Download or read book The Drug Hunters written by Donald R. Kirsch. This book was released on 2016-12-13. Available in PDF, EPUB and Kindle. Book excerpt: The surprising, behind-the-scenes story of how our medicines are discovered, told by a veteran drug hunter. The search to find medicines is as old as disease, which is to say as old as the human race. Through serendipity— by chewing, brewing, and snorting—some Neolithic souls discovered opium, alcohol, snakeroot, juniper, frankincense, and other helpful substances. Ötzi the Iceman, the five-thousand-year-old hunter frozen in the Italian Alps, was found to have whipworms in his intestines and Bronze-age medicine, a worm-killing birch fungus, knotted to his leggings. Nowadays, Big Pharma conglomerates spend billions of dollars on state-of the art laboratories staffed by PhDs to discover blockbuster drugs. Yet, despite our best efforts to engineer cures, luck, trial-and-error, risk, and ingenuity are still fundamental to medical discovery. The Drug Hunters is a colorful, fact-filled narrative history of the search for new medicines from our Neolithic forebears to the professionals of today, and from quinine and aspirin to Viagra, Prozac, and Lipitor. The chapters offer a lively tour of how new drugs are actually found, the discovery strategies, the mistakes, and the rare successes. Dr. Donald R. Kirsch infuses the book with his own expertise and experiences from thirty-five years of drug hunting, whether searching for life-saving molecules in mudflats by Chesapeake Bay or as a chief science officer and research group leader at major pharmaceutical companies.

The Body Hunters

2012-03-13 Medical
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Release : 2012-03-13
Genre : Medical
Kind : eBook
Book Rating : 310/5 ( reviews)

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Book Synopsis The Body Hunters by : Sonia Shah

Download or read book The Body Hunters written by Sonia Shah. This book was released on 2012-03-13. Available in PDF, EPUB and Kindle. Book excerpt: Hailed by John le Carré as “an act of courage on the part of its author” and singled out for praise by the leading medical journals in the United States and the United Kingdom, The Body Hunters uncovers the real-life story behind le Carré's acclaimed novel The Constant Gardener and the feature film based on it. "A trenchant exposé . . . meticulously researched and packed with documentary evidence" (Publishers Weekly), Sonia Shah's riveting journalistic account shines a much-needed spotlight on a disturbing new global trend. Drawing on years of original research and reporting in Africa and Asia, Shah examines how the multinational pharmaceutical industry, in its quest to develop lucrative drugs, has begun exporting its clinical research trials to the developing world, where ethical oversight is minimal and desperate patients abound. As the New England Journal of Medicine notes, “it is critical that those engaged in drug development, clinical research and its oversight, research ethics, and policy know about these stories,” which tell of an impossible choice being faced by many of the world's poorest patients—be experimented upon or die for lack of medicine.

Kinetics of Enzyme Action

2011-08-08 Science
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Release : 2011-08-08
Genre : Science
Kind : eBook
Book Rating : 403/5 ( reviews)

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Book Synopsis Kinetics of Enzyme Action by : Ross L. Stein

Download or read book Kinetics of Enzyme Action written by Ross L. Stein. This book was released on 2011-08-08. Available in PDF, EPUB and Kindle. Book excerpt: Few scientists have the knowledge to perform the studies that are necessary to discover and characterize enzyme inhibitors, despite the vested interest the pharmaceutical industry has in this field. Beginning with the most basic principles pertaining to simple, one-substrate enzyme reactions and their inhibitors, and progressing to a thorough treatment of two-substrate enzymes, Kinetics of Enzyme Action: Essential Principles for Drug Hunters provides biochemists, medicinal chemists, and pharmaceutical scientists with numerous case study examples to outline the tools and techniques necessary to perform, understand, and interpret detailed kinetic studies for drug discovery.

Beautiful Things

2021-04-06 Biography & Autobiography
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Release : 2021-04-06
Genre : Biography & Autobiography
Kind : eBook
Book Rating : 110/5 ( reviews)

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Book Synopsis Beautiful Things by : Hunter Biden

Download or read book Beautiful Things written by Hunter Biden. This book was released on 2021-04-06. Available in PDF, EPUB and Kindle. Book excerpt: Hunter Biden recounts his descent into substance abuse and his tortuous path to sobriety. The story ends with where Hunter is today

Manhunters

2019-11-12 True Crime
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Release : 2019-11-12
Genre : True Crime
Kind : eBook
Book Rating : 906/5 ( reviews)

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Book Synopsis Manhunters by : Steve Murphy

Download or read book Manhunters written by Steve Murphy. This book was released on 2019-11-12. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, legendary DEA operatives Steve Murphy and Javier F. Peña tell the true story of how they helped put an end to one of the world’s most infamous narco-terrorists in Manhunters: How We Took Down Pablo Escobar—the subject of the hit Netflix series, Narcos. Colombian drug lord Pablo Escobar’s brutal Medellín Cartel was responsible for trafficking tons of cocaine to North America and Europe in the 1980s and ’90s. The nation became a warzone as his sicarios mercilessly murdered thousands of people—competitors, police, and civilians—to ensure he remained Colombia’s reigning kingpin. With billions in personal income, Pablo Escobar bought off politicians and lawmen, and became a hero to poorer communities by building houses and sports centers. He was nearly untouchable despite the efforts of the Colombian National Police to bring him to justice. But Escobar was also one of America’s most wanted, and the Drug Enforcement Administration was determined to see him pay for his crimes. Agents Steve Murphy and Javier F. Peña were assigned to the Bloque de Búsqueda, the joint Colombian-U.S. taskforce created to end Escobar’s reign of terror. For eighteen months, between July 1992 and December 1993, Steve and Javier lived and worked beside Colombian authorities, finding themselves in the crosshairs of sicarios targeting them for the $300,000 bounty Escobar placed on each of their heads. Undeterred, they risked the dangers, relentlessly and ruthlessly separating the drug lord from his resources and allies, and tearing apart his empire, leaving him underground and on the run from enemies on both sides of the law. Manhunters presents Steve and Javier’s history in law enforcement from their rigorous physical training and their early DEA assignments in Miami and Austin to the Escobar mission in Medellin, Colombia—living far from home and serving as frontline soldiers in the never ending war on drugs that continues to devastate America.

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