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Autophagy and Cancer

2013-03-30 Medical
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Release : 2013-03-30
Genre : Medical
Kind : eBook
Book Rating : 613/5 ( reviews)

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Book Synopsis Autophagy and Cancer by : Hong-Gang Wang

Download or read book Autophagy and Cancer written by Hong-Gang Wang. This book was released on 2013-03-30. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it. ​

Targeting Autophagy in Cancer Therapy

2016-09-02 Medical
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Release : 2016-09-02
Genre : Medical
Kind : eBook
Book Rating : 407/5 ( reviews)

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Book Synopsis Targeting Autophagy in Cancer Therapy by : Jin-Ming Yang

Download or read book Targeting Autophagy in Cancer Therapy written by Jin-Ming Yang. This book was released on 2016-09-02. Available in PDF, EPUB and Kindle. Book excerpt: This volume will detail the current state and perspectives of autophagy-based cancer therapy. Covering a wide range of topics, it will include an overview of autophagy as a therapeutic target in cancer, autophagy modulators as cancer therapeutic agents, implications of micro-RNA-regulated autophagy in cancer therapy, modulation of autophagy through targeting PI3 kinase in cancer therapy, targeting autophagy in cancer stem cells, and roles of autophagy in cancer immunotherapy. In addition, the volume will review applications of system biology and bioinformatics approaches to discovering cancer therapeutic targets in the autophagy regulatory network. The volume will be beneficial for a variety of basic and clinical scientists, including cancer biologists, autophagy researchers, pharmacologists, and clinical oncologists who wish to delve more deeply into this field of cancer research. This volume will be the first book to focus solely on autophagy as a target in cancer therapy. As well, it will comprehensively discuss the roles of autophagy in most currently available cancer treatments.

Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies

2023-04-17 Science
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Release : 2023-04-17
Genre : Science
Kind : eBook
Book Rating : 746/5 ( reviews)

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Book Synopsis Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies by : Chen Yi

Download or read book Targeting autophagy in cancer therapy: Focus on small-molecule modulators and new strategies written by Chen Yi. This book was released on 2023-04-17. Available in PDF, EPUB and Kindle. Book excerpt:

Autophagy in tumor and tumor microenvironment

2020-10-24 Medical
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Release : 2020-10-24
Genre : Medical
Kind : eBook
Book Rating : 304/5 ( reviews)

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Book Synopsis Autophagy in tumor and tumor microenvironment by : Sujit Kumar Bhutia

Download or read book Autophagy in tumor and tumor microenvironment written by Sujit Kumar Bhutia. This book was released on 2020-10-24. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.

Autophagy

2013-09-03 Medical
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Release : 2013-09-03
Genre : Medical
Kind : eBook
Book Rating : 457/5 ( reviews)

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Book Synopsis Autophagy by : Xi Chen

Download or read book Autophagy written by Xi Chen. This book was released on 2013-09-03. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy is involved in the resistance against anticancer treatment. Both autophagy inhibitors and inducers have been demonstrated to be effective in enhancing the effect of chemotherapy and irradiation in various anticancer regimes. Currently, autophagy inhibitors are being examined in clinical trials as an adjuvant for traditional therapies. However, caution must be exercised, considering the complexity of autophagy regulation in tumorigenesis and in development of therapeutic resistance. There is also evidence suggesting that targeting autophagy may not have the desired effects. We have found that cancer cells with long-term autophagy deficiency can evade the dependence on autophagy to survive. Furthermore, some tumors are intrinsically insensitive to autophagy manipulation. Although regulation of autophagy is a promising new addition to cancer therapy, careful evaluations must be exercised when applying this strategy in clinical practice on individual bases.

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