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Surface Enhanced Raman Spectroscopy for Biophysical Applications

2018-12-05 Science
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Release : 2018-12-05
Genre : Science
Kind : eBook
Book Rating : 565/5 ( reviews)

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Book Synopsis Surface Enhanced Raman Spectroscopy for Biophysical Applications by : Claudia Fasolato

Download or read book Surface Enhanced Raman Spectroscopy for Biophysical Applications written by Claudia Fasolato. This book was released on 2018-12-05. Available in PDF, EPUB and Kindle. Book excerpt: The book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field.

Surface-Enhanced Raman Spectroscopy

2015-12-12 Science
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Release : 2015-12-12
Genre : Science
Kind : eBook
Book Rating : 929/5 ( reviews)

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Book Synopsis Surface-Enhanced Raman Spectroscopy by : Marek Prochazka

Download or read book Surface-Enhanced Raman Spectroscopy written by Marek Prochazka. This book was released on 2015-12-12. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.

Surface Enhanced Raman Spectroscopy

2011-09-19 Science
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Release : 2011-09-19
Genre : Science
Kind : eBook
Book Rating : 065/5 ( reviews)

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Book Synopsis Surface Enhanced Raman Spectroscopy by : Sebastian Schlücker

Download or read book Surface Enhanced Raman Spectroscopy written by Sebastian Schlücker. This book was released on 2011-09-19. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from the basic theoretical and practical knowledge to new exciting developments in the field with a focus on analytical and life science applications, this monograph shows how to apply surface-enhanced Raman scattering (SERS) for solving real world problems. From the contents: * Theory and practice of SERS * Analytical applications * SERS combined with other analytical techniques * Biophysical applications * Life science applications including various microscopies Aimed at analytical, surface and medicinal chemists, spectroscopists, biophysicists and materials scientists. Includes a Foreword by the renowned Raman spectroscopist Professor Wolfgang Kiefer, the former Editor-in-Chief of the Journal of Raman Spectroscopy.

Principles of Surface-Enhanced Raman Spectroscopy

2008-11-17 Science
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Release : 2008-11-17
Genre : Science
Kind : eBook
Book Rating : 553/5 ( reviews)

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Book Synopsis Principles of Surface-Enhanced Raman Spectroscopy by : Eric Le Ru

Download or read book Principles of Surface-Enhanced Raman Spectroscopy written by Eric Le Ru. This book was released on 2008-11-17. Available in PDF, EPUB and Kindle. Book excerpt: SERS was discovered in the 1970s and has since grown enormously in breadth, depth, and understanding. One of the major characteristics of SERS is its interdisciplinary nature: it lies at the boundary between physics, chemistry, colloid science, plasmonics, nanotechnology, and biology. By their very nature, it is impossible to find a textbook that will summarize the principles needed for SERS of these rather dissimilar and disconnected topics. Although a basic understanding of these topics is necessary for research projects in SERS with all its many aspects and applications, they are seldom touched upon as a coherent unit during most undergraduate studies in physics or chemistry. This book intends to fill this existing gap in the literature. It provides an overview of the underlying principles of SERS, from the fundamental understanding of the effect to its potential applications. It is aimed primarily at newcomers to the field, graduate students, researchers or scientists, attracted by the many applications of SERS and plasmonics or its basic science. The emphasis is on concepts and background material for SERS, such as Raman spectroscopy, the physics of plasmons, or colloid science, all of them introduced within the context of SERS, and from where the more specialized literature can be followed. Represents one of very few books fully dedicated to the topic of surface-enhanced Raman spectroscopy (SERS) Gives a comprehensive summary of the underlying physical concepts around SERS Provides a detailed analysis of plasmons and plasmonics

Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy

2021-09-17 Science
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Release : 2021-09-17
Genre : Science
Kind : eBook
Book Rating : 98X/5 ( reviews)

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Book Synopsis Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy by : Yuling Wang

Download or read book Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy written by Yuling Wang. This book was released on 2021-09-17. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. Introduces the basics of SERS and suitable nanomaterials for SERS application Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics

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