Author : Jozef Nauta
Release : 2010-10-07
Genre : Mathematics
Kind : eBook
Book Rating : 910/5 ( reviews)
Book Synopsis Statistics in Clinical Vaccine Trials by : Jozef Nauta
Download or read book Statistics in Clinical Vaccine Trials written by Jozef Nauta. This book was released on 2010-10-07. Available in PDF, EPUB and Kindle. Book excerpt: This monograph offers well-founded training and expertise on the statistical analysis of data from clinical vaccine trials, i.e., immunogenicity and vaccine field efficacy studies. The book's scope is practical rather than theoretical. It opens with two introductory chapters on the immunology of vaccines to provide readers with the necessary background knowledge. It then continues with an in-depth exploration of the statistical methodology. Many real-life examples and SAS codes are presented, making application of the methods straightforward. Topics discussed include maximum likelihood estimation for censored antibody titers, ANCOVA for antibody values, analysis of equivalence and non-inferiority immunogenicity trial data, analysis of data from vaccine field efficacy trials (including data from studies with recurrent infection data), fitting protection curves to data of challenge or field efficacy studies, and the analysis of vaccine safety data.