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Rational Basis for Clinical Translation in Stroke Therapy

2014-08-27 Medical
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Release : 2014-08-27
Genre : Medical
Kind : eBook
Book Rating : 977/5 ( reviews)

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Book Synopsis Rational Basis for Clinical Translation in Stroke Therapy by : Giuseppe Micieli

Download or read book Rational Basis for Clinical Translation in Stroke Therapy written by Giuseppe Micieli. This book was released on 2014-08-27. Available in PDF, EPUB and Kindle. Book excerpt: Stroke remains one of the major causes of death and long-term disability worldwide. Currently, the only approved therapy for the acute treatment of this disease is thrombolysis, a strategy that can only be applied to a small percentage of patients due to its narrow therapeutic window. Unfortunately, during the last years numerous promising drugs that showed neuroprotection in the experimental setting failed to translate into the clinic because of their toxicity or lack of efficacy. Researchers in the field now face the crucial need to develop effective stroke therapies and successfully translate novel strategies into the clinical setting. Rational Basis for Clinical Translation in Stroke Therapy presents the most recent promising preclinical approaches and the most updated clinical evidence for treating stroke patients. By bringing together the experience of accomplished stroke researchers and clinicians, the book is a useful tool for improving the treatment and management of stroke patients. The book describes current approaches for the management of stroke patients including thrombolysis and mechanical recanalization procedures as well as other clinically relevant topics such as diagnosis, imaging, risk factors, and prevention. Also described are emerging interventions based on the use of stem cells, botulinum toxin, and antidepressants which complement emergency stroke treatment and conventional rehabilitation procedures. Clinical approaches are integrated with the most promising therapeutic opportunities based on targeting the immune system, hypothermia, and postconditioning. The book also covers issues related to the improvement of R&D strategies in stroke therapeutics, aimed at the implementation of preclinical approaches with stroke model guidelines and at the optimization of clinical trial design. This volume is a reference for all those interested in the rational development of novel stroke therapeutics.

Translational Stroke Research

2012-03-23 Medical
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Release : 2012-03-23
Genre : Medical
Kind : eBook
Book Rating : 293/5 ( reviews)

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Book Synopsis Translational Stroke Research by : Paul A. Lapchak

Download or read book Translational Stroke Research written by Paul A. Lapchak. This book was released on 2012-03-23. Available in PDF, EPUB and Kindle. Book excerpt: This volume sets a basis for effective translational research. Authored by experts in the field of translational stroke research, each chapter specifically addresses one or more components of preclinical stroke research. The emphasis is placed on target identification and drug development using state-of-the-art in vitro and in vivo assays, in combination with in vitro toxicology assays, AMDE and clinical design.

Stroke Therapy

1999 Medical
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Release : 1999
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis Stroke Therapy by : Leonard P. Miller

Download or read book Stroke Therapy written by Leonard P. Miller. This book was released on 1999. Available in PDF, EPUB and Kindle. Book excerpt: Basic scientists and clinicians alike will find Stroke Therapy fascinating and informative reading. Featuring contributions from leading North American and European researchers, it is the only book covering ongoing developments in the entire breadth of the contemporary stroke therapeutic landscape-from bench to bedside. Stroke Therapy begins with an overview of the basic mechanisms and relevant animal models for studying the neuropathology of stroke, both within brain parenchyma and at the cerebrovascular level. This material is followed by an in-depth look at the ischemic cascade in light of current drug development efforts aimed at intervening at specific steps along the cascade. The final section of the book is devoted to past, present, and future directions in the development of drug therapies for stroke. Chapters explore promising drug therapies now in clinical trials, as well as key design considerations involved in developing reliable tests for the clinical effectiveness of compounds proven effective in preclinical testing. The only book covering developments in all basic and clinical aspects of pharmacological therapies for ischemic brain injury, Stroke Therapy examines important recent findings on: * The ischemic cascade and the neuropathological consequences of stroke * The latest findings on the role of cell surface receptors and channels, nitric oxide and free radicals, and various intracellular processes in stroke, including DNA damage and repair * Reparative approaches, including growth factors * Clinical aspects from trial design and in incidents of perioperative CNS dysfunction, to thrombolytic and current mechanism-based drug therapies. Stroke Therapy is a valuable working resource for scientists in academe and industry, clinical investigators, and technical managers of pharmaceutical companies involved in stroke-related research.

Disease Control Priorities, Third Edition (Volume 5)

2017-11-17 Medical
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Release : 2017-11-17
Genre : Medical
Kind : eBook
Book Rating : 202/5 ( reviews)

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Book Synopsis Disease Control Priorities, Third Edition (Volume 5) by : Dorairaj Prabhakaran

Download or read book Disease Control Priorities, Third Edition (Volume 5) written by Dorairaj Prabhakaran. This book was released on 2017-11-17. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular, respiratory, and related conditions cause more than 40 percent of all deaths globally, and their substantial burden is rising, particularly in low- and middle-income countries (LMICs). Their burden extends well beyond health effects to include significant economic and societal consequences. Most of these conditions are related, share risk factors, and have common control measures at the clinical, population, and policy levels. Lives can be extended and improved when these diseases are prevented, detected, and managed. This volume summarizes current knowledge and presents evidence-based interventions that are effective, cost-effective, and scalable in LMICs.

Clinical Pathways in Stroke Rehabilitation

2021-01-14 Medical
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Release : 2021-01-14
Genre : Medical
Kind : eBook
Book Rating : 050/5 ( reviews)

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Book Synopsis Clinical Pathways in Stroke Rehabilitation by : Thomas Platz

Download or read book Clinical Pathways in Stroke Rehabilitation written by Thomas Platz. This book was released on 2021-01-14. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on practical clinical problems that are frequently encountered in stroke rehabilitation. Consequences of diseases, e.g. impairments and activity limitations, are addressed in rehabilitation with the overall goal to reduce disability and promote participation. Based on the available best external evidence, clinical pathways are described for stroke rehabilitation bridging the gap between clinical evidence and clinical decision-making. The clinical pathways answer the questions which rehabilitation treatment options are beneficial to overcome specific impairment constellations and activity limitations and are well acceptable to stroke survivors, as well as when and in which settings to provide rehabilitation over the course of recovery post stroke. Each chapter starts with a description of the clinical problem encountered. This is followed by a systematic, but concise review of the evidence (RCTs, systematic reviews and meta-analyses) that is relevant for clinical decision-making, and comments on assessment, therapy (training, technology, medication), and the use of technical aids as appropriate. Based on these summaries, clinical algorithms / pathways are provided and the main clinical-decision situations are portrayed. The book is invaluable for all neurorehabilitation team members, clinicians, nurses, and therapists in neurology, physical medicine and rehabilitation, and related fields. It is a World Federation for NeuroRehabilitation (WFNR) educational initiative, bridging the gap between the rapidly expanding clinical research in stroke rehabilitation and clinical practice across societies and continents. It can be used for both clinical decision-making for individuals and as well as clinical background knowledge for stroke rehabilitation service development initiatives.

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