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Quasispecies: From Theory to Experimental Systems

2016-03-18 Medical
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Release : 2016-03-18
Genre : Medical
Kind : eBook
Book Rating : 981/5 ( reviews)

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Book Synopsis Quasispecies: From Theory to Experimental Systems by : Esteban Domingo

Download or read book Quasispecies: From Theory to Experimental Systems written by Esteban Domingo. This book was released on 2016-03-18. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together recent developments in quasispecies theory extended to variable environments and practical applications in elucidating viral dynamics and treatment designs. In particular, the existence of an error threshold in rugged fitness landscapes has opened the way to a new antiviral strategy termed lethal mutagenesis, which is now under intensive theoretical, experimental and clinical investigation. As such the book explains how an understanding of quasispecies dynamics within infected organisms has increased our knowledge of viral disease events. From a clinical perspective, population dynamics highlights important problems for viral disease control, such as the selection of drug-resistant mutants that often accompanies treatment failures, and suggests means of increasing the effectiveness of antiviral treatments. The book is intended for students and scientists interested in basic and applied aspects of biophysics, chemistry, biology, evolution and medical virology.

Virus as Populations

2019-11-06 Science
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Release : 2019-11-06
Genre : Science
Kind : eBook
Book Rating : 321/5 ( reviews)

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Book Synopsis Virus as Populations by : Esteban Domingo

Download or read book Virus as Populations written by Esteban Domingo. This book was released on 2019-11-06. Available in PDF, EPUB and Kindle. Book excerpt: Virus as Composition, Complexity, Quasispecies, Dynamics, and Biological Implications, Second Edition, explains the fundamental concepts surrounding viruses as complex populations during replication in infected hosts. Fundamental phenomena in virus behavior, such as adaptation to changing environments, capacity to produce disease, and the probability to be transmitted or respond to treatment all depend on virus population numbers. Concepts such as quasispecies dynamics, mutations rates, viral fitness, the effect of bottleneck events, population numbers in virus transmission and disease emergence, and new antiviral strategies are included. The book's main concepts are framed by recent observations on general virus diversity derived from metagenomic studies and current views on the origin and role of viruses in the evolution of the biosphere. - Features current views on key steps in the origin of life and origins of viruses - Includes examples relating ancestral features of viruses with their current adaptive capacity - Explains complex phenomena in an organized and coherent fashion that is easy to comprehend and enjoyable to read - Considers quasispecies as a framework to understand virus adaptability and disease processes

Origin and Evolution of Viruses

2008-06-23 Science
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Release : 2008-06-23
Genre : Science
Kind : eBook
Book Rating : 968/5 ( reviews)

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Book Synopsis Origin and Evolution of Viruses by : Esteban Domingo

Download or read book Origin and Evolution of Viruses written by Esteban Domingo. This book was released on 2008-06-23. Available in PDF, EPUB and Kindle. Book excerpt: New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases. - NEW - methods to establish relationships among viruses and the mechanisms that affect virus evolution - UNIQUE - combines theoretical concepts in evolution with detailed analyses of the evolution of important virus groups - SPECIFIC - Bacterial, plant, animal and human viruses are compared regarding their interation with their hosts

Quasispecies: Concept and Implications for Virology

2006-02-19 Medical
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Release : 2006-02-19
Genre : Medical
Kind : eBook
Book Rating : 977/5 ( reviews)

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Book Synopsis Quasispecies: Concept and Implications for Virology by : Esteban Domingo

Download or read book Quasispecies: Concept and Implications for Virology written by Esteban Domingo. This book was released on 2006-02-19. Available in PDF, EPUB and Kindle. Book excerpt: Continuous genetic variation and selection of virus subpopulations in the course of RNA virus replications are intimately related to viral disease mechanisms. The central topics of this volume are the origins of the quasispecies concept, and the implications of quasispecies dynamics for viral populations.

Advanced Mathematical Methods in Biosciences and Applications

2019-09-19 Mathematics
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Release : 2019-09-19
Genre : Mathematics
Kind : eBook
Book Rating : 156/5 ( reviews)

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Book Synopsis Advanced Mathematical Methods in Biosciences and Applications by : Faina Berezovskaya

Download or read book Advanced Mathematical Methods in Biosciences and Applications written by Faina Berezovskaya. This book was released on 2019-09-19. Available in PDF, EPUB and Kindle. Book excerpt: Featuring contributions from experts in mathematical biology and biomedical research, this edited volume covers a diverse set of topics on mathematical methods and applications in the biosciences. Topics focus on advanced mathematical methods, with chapters on the mathematical analysis of the quasispecies model, Arnold’s weak resonance equation, bifurcation analysis, and the Tonnelier-Gerstner model. Special emphasis is placed on applications such as natural selection, population heterogeneity, polyvariant ontogeny in plants, cancer dynamics, and analytical solutions for traveling pulses and wave trains in neural models. A survey on quasiperiodic topology is also presented in this book. Carefully peer-reviewed, this volume is suitable for students interested in interdisciplinary research. Researchers in applied mathematics and the biosciences will find this book an important resource on the latest developments in the field. In keeping with the STEAM-H series, the editors hope to inspire interdisciplinary understanding and collaboration.

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