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Protein-Protein Interactions

2012-03-30 Science
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Release : 2012-03-30
Genre : Science
Kind : eBook
Book Rating : 970/5 ( reviews)

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Book Synopsis Protein-Protein Interactions by : Weibo Cai

Download or read book Protein-Protein Interactions written by Weibo Cai. This book was released on 2012-03-30. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.

Proteomics and Protein-Protein Interactions

2006-12-22 Medical
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Release : 2006-12-22
Genre : Medical
Kind : eBook
Book Rating : 324/5 ( reviews)

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Book Synopsis Proteomics and Protein-Protein Interactions by : Gabriel Waksman

Download or read book Proteomics and Protein-Protein Interactions written by Gabriel Waksman. This book was released on 2006-12-22. Available in PDF, EPUB and Kindle. Book excerpt: Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London WC1E 7H United Kingdom Email: g. waksman@bbk. ac. uk and g. waksman@ucl. ac. uk Phone: (+44) (0) 207 631 6833 Fax: (+44) (0) 207 631 6833 URL: http://people. cryst. bbk. ac. uk/?ubcg54a Gabriel Waksman is Professor of Structural Molecular Biology at the Institute of Structural Molecular Biology at UCL/Birkbeck, of which he is also the director. Before joining the faculty of UCL and Birkbeck, he was the Roy and Diana Vagelos Professor of Biochemistry and Molecular Biophysics at the Washington University School of Medicine in St Louis (USA). The rapidly evolving ?eld of protein science has now come to realize the ubiquity and importance of protein–protein interactions. It had been known for some time that proteins may interact with each other to form functional complexes, but it was thought to be the property of only a handful of key proteins. However, with the advent of hi- throughput proteomics to monitor protein–protein interactions at an organism level, we can now safely state that protein–protein interactions are the norm and not the exception.

Computational Protein-Protein Interactions

2009-06-26 Science
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Release : 2009-06-26
Genre : Science
Kind : eBook
Book Rating : 07X/5 ( reviews)

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Book Synopsis Computational Protein-Protein Interactions by : Ruth Nussinov

Download or read book Computational Protein-Protein Interactions written by Ruth Nussinov. This book was released on 2009-06-26. Available in PDF, EPUB and Kindle. Book excerpt: Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current resear

Protein Interactions

2007-03-20 Science
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Release : 2007-03-20
Genre : Science
Kind : eBook
Book Rating : 664/5 ( reviews)

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Book Synopsis Protein Interactions by : Peter Schuck

Download or read book Protein Interactions written by Peter Schuck. This book was released on 2007-03-20. Available in PDF, EPUB and Kindle. Book excerpt: This volume successfully and clearly examines how biophysical approaches can be used to study complex systems of reversibly interacting proteins. It deals with the methodology behind the research and shows how to synergistically incorporate several methodologies for use. Each chapter treats and introduces the reader to different biological systems, includes a brief summary of the physical principles, and mentions practical requirements.

Protein Interactions: Computational Methods, Analysis And Applications

2020-03-05 Science
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Release : 2020-03-05
Genre : Science
Kind : eBook
Book Rating : 884/5 ( reviews)

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Book Synopsis Protein Interactions: Computational Methods, Analysis And Applications by : M Michael Gromiha

Download or read book Protein Interactions: Computational Methods, Analysis And Applications written by M Michael Gromiha. This book was released on 2020-03-05. Available in PDF, EPUB and Kindle. Book excerpt: This book is indexed in Chemical Abstracts ServiceThe interactions of proteins with other molecules are important in many cellular activities. Investigations have been carried out to understand the recognition mechanism, identify the binding sites, analyze the the binding affinity of complexes, and study the influence of mutations on diseases. Protein interactions are also crucial in structure-based drug design.This book covers computational analysis of protein-protein, protein-nucleic acid and protein-ligand interactions and their applications. It provides up-to-date information and the latest developments from experts in the field, using illustrations to explain the key concepts and applications. This volume can serve as a single source on comparative studies of proteins interacting with proteins/DNAs/RNAs/carbohydrates and small molecules.

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