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Protein Interaction Networks

2009-04-06 Computers
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Release : 2009-04-06
Genre : Computers
Kind : eBook
Book Rating : 032/5 ( reviews)

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Book Synopsis Protein Interaction Networks by : Aidong Zhang

Download or read book Protein Interaction Networks written by Aidong Zhang. This book was released on 2009-04-06. Available in PDF, EPUB and Kindle. Book excerpt: The analysis of protein-protein interactions is fundamental to the understanding of cellular organization, processes, and functions. Proteins seldom act as single isolated species; rather, proteins involved in the same cellular processes often interact with each other. Functions of uncharacterized proteins can be predicted through comparison with the interactions of similar known proteins. Recent large-scale investigations of protein-protein interactions using such techniques as two-hybrid systems, mass spectrometry, and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein-protein interaction networks. The resulting large volume of protein-protein interaction data has posed a challenge to experimental investigation. This book provides a comprehensive understanding of the computational methods available for the analysis of protein-protein interaction networks. It offers an in-depth survey of a range of approaches, including statistical, topological, data-mining, and ontology-based methods. The author discusses the fundamental principles underlying each of these approaches and their respective benefits and drawbacks, and she offers suggestions for future research.

Biological Data Mining in Protein Interaction Networks

2009-05-31 Technology & Engineering
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Release : 2009-05-31
Genre : Technology & Engineering
Kind : eBook
Book Rating : 999/5 ( reviews)

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Book Synopsis Biological Data Mining in Protein Interaction Networks by : Li, Xiao-Li

Download or read book Biological Data Mining in Protein Interaction Networks written by Li, Xiao-Li. This book was released on 2009-05-31. Available in PDF, EPUB and Kindle. Book excerpt: "The goal of this book is to disseminate research results and best practices from cross-disciplinary researchers and practitioners interested in, and working on bioinformatics, data mining, and proteomics"--Provided by publisher.

Protein-Protein Interaction Networks

2019-10-04 Science
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Release : 2019-10-04
Genre : Science
Kind : eBook
Book Rating : 722/5 ( reviews)

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Book Synopsis Protein-Protein Interaction Networks by : Stefan Canzar

Download or read book Protein-Protein Interaction Networks written by Stefan Canzar. This book was released on 2019-10-04. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores techniques that study interactions between proteins in different species, and combines them with context-specific data, analysis of omics datasets, and assembles individual interactions into higher-order semantic units, i.e., protein complexes and functional modules. The chapters in this book cover computational methods that solve diverse tasks such as the prediction of functional protein-protein interactions; the alignment-based comparison of interaction networks by SANA; using the RaptorX-ComplexContact webserver to predict inter-protein residue-residue contacts; the docking of alternative confirmations of proteins participating in binary interactions and the visually-guided selection of a docking model using COZOID; the detection of novel functional units by KeyPathwayMiner and how PathClass can use such de novo pathways to classify breast cancer subtypes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary hardware- and software, step-by-step, readily reproducible computational protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Protein-Protein Interaction Networks: Methods and Protocols is a valuable resource for both novice and expert researchers who are interested in learning more about this evolving field.

New Approaches of Protein Function Prediction from Protein Interaction Networks

2017-01-13 Mathematics
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Release : 2017-01-13
Genre : Mathematics
Kind : eBook
Book Rating : 445/5 ( reviews)

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Book Synopsis New Approaches of Protein Function Prediction from Protein Interaction Networks by : Jingyu Hou

Download or read book New Approaches of Protein Function Prediction from Protein Interaction Networks written by Jingyu Hou. This book was released on 2017-01-13. Available in PDF, EPUB and Kindle. Book excerpt: New Approaches of Protein Function Prediction from Protein Interaction Networks contains the critical aspects of PPI network based protein function prediction, including semantically assessing the reliability of PPI data, measuring the functional similarity between proteins, dynamically selecting prediction domains, predicting functions, and establishing corresponding prediction frameworks. Functional annotation of proteins is vital to biological and clinical research and other applications due to the important roles proteins play in various biological processes. Although the functions of some proteins have been annotated via biological experiments, there are still many proteins whose functions are yet to be annotated due to the limitations of existing methods and the high cost of experiments. To overcome experimental limitations, this book helps users understand the computational approaches that have been rapidly developed for protein function prediction. Provides innovative approaches and new developments targeting key issues in protein function prediction Presents heuristic ideas for further research in this challenging area

The Autoimmune Diseases

1998 Medical
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Release : 1998
Genre : Medical
Kind : eBook
Book Rating : /5 ( reviews)

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Book Synopsis The Autoimmune Diseases by : Noel R. Rose

Download or read book The Autoimmune Diseases written by Noel R. Rose. This book was released on 1998. Available in PDF, EPUB and Kindle. Book excerpt: The Autoimmune Diseases comprehensively describes the clinical expressions of all known autoimmune diseases, as well as the experimental bases of autoimmunity and failure of tolerance. The scientific chapters include mechanisms of natural tolerance, the genetic basis of autoimmunity, the significance of apoptosis, the influence of cytokines, environmental influences, and experimental models. The clinical chapters cover autoimmune endocrine deficiencies, insulin-dependent diabetes, rheumatic disorders, neurological diseases, and diseases of the blood, skin, eye, kidney, and liver.

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