Share

Protein Kinases as Drug Targets

2011-03-16 Science
Download Protein Kinases as Drug Targets PDF Online Free

Author :
Release : 2011-03-16
Genre : Science
Kind : eBook
Book Rating : 499/5 ( reviews)

GET EBOOK


Book Synopsis Protein Kinases as Drug Targets by : Bert Klebl

Download or read book Protein Kinases as Drug Targets written by Bert Klebl. This book was released on 2011-03-16. Available in PDF, EPUB and Kindle. Book excerpt: This timely guide to kinase inhibitor drug development is the first to cover the entire drug pipeline, from target identification to compound development and clinical application. Edited by the pioneers in the field, on the drug development side this ready reference discusses classical medicinal chemistry approaches as well as current chemical genomics strategies. On the clinical side, both current and future therapeutic application areas for kinase inhibitor drugs are addressed, with a strong focus on oncology drugs. Backed by recent clinical experience with first-generation drugs in the battle against various forms of cancer, this is crucial reading for medicinal, pharmaceutical and biochemists, molecular biologists, and oncologists, as well as those working in the pharmaceutical industry.

Kinase Drug Discovery

2012 Medical
Download Kinase Drug Discovery PDF Online Free

Author :
Release : 2012
Genre : Medical
Kind : eBook
Book Rating : 748/5 ( reviews)

GET EBOOK


Book Synopsis Kinase Drug Discovery by : Richard A. Ward

Download or read book Kinase Drug Discovery written by Richard A. Ward. This book was released on 2012. Available in PDF, EPUB and Kindle. Book excerpt: Kinase drug discovery remains an area of significant interest across academia and in the pharmaceutical industry. There are now around 13 FDA approved small molecule drugs which target kinases and many more compounds in various stages of clinical development. Although there have been a number of reviews/publications on kinase research, this book fills a gap in the literature by considering the current and future opportunities and challenges in targeting this important family of enzymes. The book is forward-looking and identifies a number of hot topics and key areas for kinase drug discovery over the coming years. It includes contributions from highly respected authors with a combined experience in the industry of well over 200 years, which has resulted in a book of great interest to the kinase field and across drug discovery more generally. Readers will gain a real insight into the huge challenges and opportunities which this target class has presented drug discovery scientists. The many chapters cover a wide breadth of topics, are well written and include high quality colour and black and white images. Topics covered include an outline of how medicinal chemistry has been able to specifically exploit this unique target class, along with reflections on the mechanisms of kinases inhibitors. Also covered is resistance to kinase inhibitors caused by amino acid mutations, case studies of kinase programs and reviews areas beyond protein kinases and beyond the human kinome. Also described are modern approaches to finding kinase leads and the book finishes with a reflection of how kinase drug discovery may progress over the coming years.

Protein Kinases

2021-12-08 Medical
Download Protein Kinases PDF Online Free

Author :
Release : 2021-12-08
Genre : Medical
Kind : eBook
Book Rating : 066/5 ( reviews)

GET EBOOK


Book Synopsis Protein Kinases by :

Download or read book Protein Kinases written by . This book was released on 2021-12-08. Available in PDF, EPUB and Kindle. Book excerpt: For the past two decades, the protein kinase family has been an intense area of research for developing anticancer drugs. Despite tremendous advancements in kinase drug expansion, many kinases are still unexplored. As such, this book includes research and review articles from experts that focus on protein kinase signalling pathways as a molecular drug target. Chapters include illustrations and cover such topics as the mechanism of action and anticancer activity of protein kinase inhibitors on various cancer types. They also discuss new opportunities, challenges, and future perspectives in the field.

Protein Kinases in Drug Discovery

2021-03-11 Science
Download Protein Kinases in Drug Discovery PDF Online Free

Author :
Release : 2021-03-11
Genre : Science
Kind : eBook
Book Rating : 137/5 ( reviews)

GET EBOOK


Book Synopsis Protein Kinases in Drug Discovery by : Rossen Donev

Download or read book Protein Kinases in Drug Discovery written by Rossen Donev. This book was released on 2021-03-11. Available in PDF, EPUB and Kindle. Book excerpt: Protein Kinases in Drug Discovery, Volume 124 discusses the latest information on protein kinases and how they modify other proteins by chemically adding phosphate groups to them. New chapters in this release include Transport Proteins and AMPs: Implications in Human Disease, Protein kinase CK2 inhibition as a pharmacological strategy, Emerging role of Protein kinase in diabetes mellitus: From Mechanism to therapy, Dual Roles of ATP-binding site in Protein Kinases: Orthosteric inhibition and Allosteric Regulation, Pseudokinases in drug discovery and development: progress, challenges and future prospects, Comparison of knowledge-based vs. combinatorial peptide library approaches for the identification of protein kinase substrates, and more. Contains timely chapters written by well-renown authorities in their field Includes a number of high-quality illustrations, figures and tables, and targets a very wide audience of specialists, researchers and students Integrates experimental and computational methods for studying the role of protein kinases in different diseases, along with sections on the design of suitable protein kinase inhibitors for use in the treatment of patients

Protein Tyrosine Kinases

2007-11-13 Science
Download Protein Tyrosine Kinases PDF Online Free

Author :
Release : 2007-11-13
Genre : Science
Kind : eBook
Book Rating : 621/5 ( reviews)

GET EBOOK


Book Synopsis Protein Tyrosine Kinases by : Doriano Fabbro

Download or read book Protein Tyrosine Kinases written by Doriano Fabbro. This book was released on 2007-11-13. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers, from the Novartis group that pioneered Gleevec/GlivecTM and around the world, comprehensively survey the state of the art in the drug discovery processes (bio- and chemoinformatics, structural biology, profiling, generation of resistance, etc.) aimed at generating PTK inhibitors for the treatment of various diseases, including cancer. Highlights include a discussion of the rationale and the progress made towards generating "selective" low molecular-weight kinase inhibitors; an analysis of the normal function, role in disease, and application of platelet-derived growth factor antagonists; and a summary of the factors involved in successful structure-based drug design. Additional chapters address the advantages and disadvantages of in vivo preclinical models for testing protein kinase inhibitors with antitumor activity and the utility of different methods in the drug discovery and development process for determining "on-target" vs "off-target" effects of kinase inhibitors.

You may also like...