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Principles of Cancer Treatment and Anticancer Drug Development

2019 Cancer
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Release : 2019
Genre : Cancer
Kind : eBook
Book Rating : 231/5 ( reviews)

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Book Synopsis Principles of Cancer Treatment and Anticancer Drug Development by : Wolfgang Alexander Link

Download or read book Principles of Cancer Treatment and Anticancer Drug Development written by Wolfgang Alexander Link. This book was released on 2019. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Principles of Cancer Treatment and Anticancer Drug Development

2019-09-10 Medical
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Release : 2019-09-10
Genre : Medical
Kind : eBook
Book Rating : 225/5 ( reviews)

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Book Synopsis Principles of Cancer Treatment and Anticancer Drug Development by : Wolfgang Link

Download or read book Principles of Cancer Treatment and Anticancer Drug Development written by Wolfgang Link. This book was released on 2019-09-10. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical development until its approval by regulatory authorities. Particular emphasis has been given to specific aspects of the development process including lead generation and optimization, pharmacokinetics, ADME analysis, pharmacodynamics, toxicity and efficacy assessment, investigational new drug (IND) and new drug application (NDA) and the design of clinical trial and their phases. The book covers many aspects of modern personalized oncology and discusses economic aspects of our current system of developing new medicines and its impact on our societies and on future drug research. The author of this book, Dr. Link counts with more than 20 years of experience in biomedical research reflected in numerous publications, patents and key note and plenary presentations at international conferences. Interested readers, students and teachers should read this book as it provides a unique way to learn/teach about basic concepts in oncology and anti-cancer drug research.

Principles of Anticancer Drug Development

2010-12-29 Medical
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Release : 2010-12-29
Genre : Medical
Kind : eBook
Book Rating : 583/5 ( reviews)

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Book Synopsis Principles of Anticancer Drug Development by : Elizabeth Garrett-Mayer

Download or read book Principles of Anticancer Drug Development written by Elizabeth Garrett-Mayer. This book was released on 2010-12-29. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to the design, conduction, analysis and reporting of clinical trials with anticancer drugs.

Cancer Chemotherapy and Biotherapy

2011-12-07 Medical
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Release : 2011-12-07
Genre : Medical
Kind : eBook
Book Rating : 208/5 ( reviews)

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Book Synopsis Cancer Chemotherapy and Biotherapy by : Bruce A. Chabner

Download or read book Cancer Chemotherapy and Biotherapy written by Bruce A. Chabner. This book was released on 2011-12-07. Available in PDF, EPUB and Kindle. Book excerpt: Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other agents, toxicities, side effects, and mechanisms of resistance. The authors explain the rationale for use of drugs in specific schedules and combinations and offer guidelines for dose adjustment in particular situations. This edition's introduction includes timely information on general strategies for drug usage, the science of drug discovery and development, economic and regulatory aspects of cancer drug development, and principles of pharmacokinetics. Eight new chapters have been added and more than twenty have been significantly revised. A companion website includes the fully searchable text and an image bank.

An Introduction to the Use of Anticancer Drugs

2006-01-01 Medical
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Release : 2006-01-01
Genre : Medical
Kind : eBook
Book Rating : 300/5 ( reviews)

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Book Synopsis An Introduction to the Use of Anticancer Drugs by : Imran Rafi

Download or read book An Introduction to the Use of Anticancer Drugs written by Imran Rafi. This book was released on 2006-01-01. Available in PDF, EPUB and Kindle. Book excerpt: This title is directed primarily towards health care professionals outside of the United States. The aim of this book is to provide an introduction to the principles of drug treatment for solid tumours in cancer medicine. Developments in the understanding of tumour biology, molecular biology and genetics - together with the greater understanding of the pharmacology and pharmacokinetics of drugs - have combined to open up the field of medical oncology to rapid advances in the treatment of cancers. The range of drugs that are available is wide and one of the primary aims in drug development is to increase the therapeutic window so that drug toxicity is minimised and tolerable. Drug development of oral formulations of anticancer drugs and the use of drugs that could be given in the day patient setting means that healthcare professionals such as general practitioners - who historically might not have been involved in the drug treatment of the cancer patient - are now going to need to have a greater understanding of the principles of use of anticancer drugs. This book is primarily aimed at this market. Basic principles of drug treatment - develops an understanding of why and when anticancer drugs are used. Covers the purpose of clinical trials in oncology from Phase I to Phase IV trials in drug development. Discusses the organisation of clinical networks in the UK. Case studies in cancer treatment, allowing an understanding of when and why the typical regimes are used. NICE guidelines.

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