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Pharmaceutical Preformulation and Formulation

2016-04-19 Medical
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Release : 2016-04-19
Genre : Medical
Kind : eBook
Book Rating : 184/5 ( reviews)

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Book Synopsis Pharmaceutical Preformulation and Formulation by : Mark Gibson

Download or read book Pharmaceutical Preformulation and Formulation written by Mark Gibson. This book was released on 2016-04-19. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical Preformulation and Formulation: A Practical Guide from Candidate Drug Selection to Commercial Dosage Form reflects the mounting pressure on pharmaceutical companies to accelerate the new drug development and launch process, as well as the shift from developing small molecules to the growth of biopharmaceuticals. The book meets the ne

Essentials of Pharmaceutical Preformulation

2012-10-22 Science
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Release : 2012-10-22
Genre : Science
Kind : eBook
Book Rating : 240/5 ( reviews)

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Book Synopsis Essentials of Pharmaceutical Preformulation by : Simon Gaisford

Download or read book Essentials of Pharmaceutical Preformulation written by Simon Gaisford. This book was released on 2012-10-22. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of Pharmaceutical Preformulation is a study guide which describes the basic principles of pharmaceutical physicochemical characterisation. Successful preformulation requires knowledge of fundamental molecular concepts (solubility, ionisation, partitioning, hygroscopicity and stability) and macroscopic properties (physical form, such as the crystalline and amorphous states, hydrates, solvates and co-crystals and powder properties), familiarity with the techniques used to measure them and appreciation of their effect on product performance, recognising that often there is a position of compromise to be reached between product stability and bioavailability. This text introduces the basic concepts and discusses their wider implication for pharmaceutical development, with reference to many case examples of current drugs and drug products. Special attention is given to the principles and best-practice of the analytical techniques that underpin preformulation (UV spectrophotometry, TLC, DSC, XRPD and HPLC). The material is presented in the typical order that would be followed when developing a medicine and maps onto the indicative pharmacy syllabus of the Royal Pharmaceutical Society of Great Britain Undergraduate-level pharmacy students and R&D / analytical scientists working in the pharmaceutical sector (with or without a pharmaceutical background) will find this text easy to follow with relevant pharmaceutical examples. Essential study guide for pharmacy and pharmaceutical science students Covers the pharmaceutical preformulation components of the Royal Pharmaceutical Society of Great Britain’s indicative syllabus Easy to follow text highlighted with relevant pharmaceutical examples Self-assessment assignments in a variety of formats Written by authors with both academic and industrial experience Companion website with further information to maximise learning

Preformulation in Solid Dosage Form Development

2008-01-07 Medical
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Release : 2008-01-07
Genre : Medical
Kind : eBook
Book Rating : 097/5 ( reviews)

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Book Synopsis Preformulation in Solid Dosage Form Development by : Moji Christianah Adeyeye

Download or read book Preformulation in Solid Dosage Form Development written by Moji Christianah Adeyeye. This book was released on 2008-01-07. Available in PDF, EPUB and Kindle. Book excerpt: During the onset of any clinical trial there are many factors and variables to consider. Funding, time restraints, and regulatory agency guidelines are factors that often influence which variables will be studied, leaving other important information out of the study. Preformulation in Solid Dosage Form Development covers every topic of critical importance to the preformulation stages of drug development. Serving as a handbook or stand-alone reference, this text equips those in academia and the pharmaceutical industry with both basic and applied principles for the characterization of drugs, excipients, and products, and deals with the issues relating to predictability, identification, and product development during preformulation stages through Phase I of clinical trials. With contributions from an international panel of experts in the field, this guide: outlines an updated preformulation program for modern drug development issues that includes particle morphology, characterization, thermal analysis, and solubility methods contains rational designs for the structure of formulation studies covers the importance of preformulation design using artificial neural networks and computational prediction techniques, and examines the concepts of preliminary-preformulation discusses the typical drug-excipient interactions that could occur during the course of development and methods of characterization includes novel methods to determine the physical and chemical stability of new formulations reviews the structure, content, and format of the preformulation report examines the significance of drug substance physiochemical properties, in regulatory quality by design

Pharmaceutical Preformulation

1998-07-07 Medical
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Release : 1998-07-07
Genre : Medical
Kind : eBook
Book Rating : 906/5 ( reviews)

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Book Synopsis Pharmaceutical Preformulation by : Jens T. Carstensen

Download or read book Pharmaceutical Preformulation written by Jens T. Carstensen. This book was released on 1998-07-07. Available in PDF, EPUB and Kindle. Book excerpt: FROM THE PREFACE This book addresses problems and solutions of formulation and preformulation with which I have concerned myself for 34 years. When I was employed in the pharmaceutical industry I worked at functions, in the 1960's, which were the precursors of preformulation, and my early publications dealt with such matters. In the following decades advances have been made in methodology and the realm of preformulation has grown. Theory and the way in which problems are viewed have also undergone change. The text deals with the pharmaceutical aspects of preformulation, not the synthetic nor the analytical aspects. It takes its vantage point at the point in time when the pharmaceutical preformulator first obtains a sample of the drug substance, and it explores the physical, chemical and technological aspects that are needed for a full exploration of the potential advantages and disadvantages of the drug substance. It is only through the understanding of underlying principles that adequate exploration can be carried out.

Handbook of Preformulation

2006-09-18 Medical
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Release : 2006-09-18
Genre : Medical
Kind : eBook
Book Rating : 622/5 ( reviews)

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Book Synopsis Handbook of Preformulation by : Sarfaraz K. Niazi

Download or read book Handbook of Preformulation written by Sarfaraz K. Niazi. This book was released on 2006-09-18. Available in PDF, EPUB and Kindle. Book excerpt: Preformulation studies are the physical, chemical, and biological studies needed to characterize a drug substance for enabling the proper design of a drug product, whereas the effectiveness of a drug product is determined during the formulation studies phase. Though the two disciplines overlap in practice, each is a significantly distinct phase of

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